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Image of CD4 co-receptor binding to MHC (Major Histocompatibility Complex) non-polymorphic region. In molecular biology, CD4 (cluster of differentiation 4) is a glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). CD4 is found on the surface of immune cells such as helper T cells, monocytes, macrophages, and dendritic cells.
The CD family of co-receptors are a well-studied group of extracellular receptors found in immunological cells. [4] The CD receptor family typically act as co-receptors, illustrated by the classic example of CD4 acting as a co-receptor to the T cell receptor (TCR) to bind major histocompatibility complex II (MHC-II). [5]
CD47-binding is mediated through the NH2-terminal V-like domain of SIRP α. The cytoplasmic region contains four ITIMs that become phosphorylated after binding of ligand. The phosphorylation mediates activation of tyrosine kinase SHP2. SIRP α has been shown to bind also phosphatase SHP1, adaptor protein SCAP2 and FYN-binding protein.
In programming and software design, a binding is an application programming interface (API) that provides glue code specifically made to allow a programming language to use a foreign library or operating system service (one that is not native to that language).
Linux is a Unix-like computer operating system assembled under the model of free and open-source software development and distribution. Most Linux distributions , as collections of software based around the Linux kernel and often around a package management system , provide complete LAMP setups through their packages.
Official tier-2 support exists for Linux for 64-bit ARM, wasm32 (Web Assembly) with WASI runtime support, and Linux for 64-bit Intel using a clang toolchain. Official supported tier-3 systems include 64-bit ARM Windows, 64-bit iOS, Raspberry Pi OS (Linux for armv7 with hard float), Linux for 64-bit PowerPC in little-endian mode, and Linux for ...
Anaconda, Inc. compiles and builds the packages available in the Anaconda repository itself, and provides binaries for Windows 32/64 bit, Linux 64 bit and MacOS 64-bit (Intel, Apple Silicon). Anything available on PyPI may be installed into a Conda environment using pip, and Conda will keep track of what it has installed and what pip has installed.
Snap is a software packaging and deployment system developed by Canonical for operating systems that use the Linux kernel and the systemd init system. The packages, called snaps, and the tool for using them, snapd, work across a range of Linux distributions [3] and allow upstream software developers to distribute their applications directly to users.