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The BIC Cristal (stylised as BiC Cristal and also known as the Bic Biro) is an inexpensive, disposable ballpoint pen mass-produced and sold by Société Bic of Clichy, Hauts-de-Seine, France. [1] It was introduced in 1950 and is the best-selling pen in the world, with the 100 billionth sold in September 2006.
In 1969, Bic launched its advertising campaign in the United States. A year later, the four-color Bic was launched. The four-color pen allowed one to change the ink color without changing the pen. [13] Bic's ability to mass produce the manufacturing of their pens resulted in low prices. [14] The Conté company was acquired by BIC in 1979. [15]
It was a combination of the lipid-modifying drug/vitamin niacin in extended release form and the statin drug lovastatin (trade name Mevacor). [1] The combination preparation was developed by Kos Pharmaceuticals, Inc., which was acquired by Abbott Laboratories in 2006, subsequently transferred to AbbVie Inc. when that company was spun off from ...
Niacin is available as a prescription product, either immediate release (500 mg tablets; prescribed up to 3,000 mg/day) or extended release (500 and 1,000 mg tablets; prescribed up to 2,000 mg/day). In the US, niacin is also available as a dietary supplement at 500 to 1,000 mg/tablet. Niacin has sometimes been used in combination with other ...
This page was last edited on 21 August 2008, at 14:43 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; additional terms may ...
Example of a label showing the amount of niacin (Vitamin B3), and specifying to be niacinamide in the ingredient section.. The United States Government adopted the terms niacin and niacinamide in 1942 as alternate names for nicotinic acid and nicotinamide, respectively, and encouraged their use in nontechnical contexts to avoid the public’s confusing them with the nearly unrelated (and toxic ...
A man with pellagra, which is caused by a chronic lack of vitamin B 3 in the diet. Severe deficiency of niacin in the diet causes the disease pellagra, characterized by diarrhea, sun-sensitive dermatitis involving hyperpigmentation and thickening of the skin (see image), inflammation of the mouth and tongue, delirium, dementia, and if left untreated, death. [7]
Nicotinamide (INN, BAN UK [2]) or niacinamide (USAN US) is a form of vitamin B 3 found in food and used as a dietary supplement and medication. [3] [4] [5] As a supplement, it is used orally (swallowed by mouth) to prevent and treat pellagra (niacin deficiency). [4]
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