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A new study distinguishes between two distinct phases of Alzheimer's disease: an early, 'stealth' one without symptoms, and a second phase that aggressively damages the brain.
Dementia directly affects more than 55 million people worldwide, and up to 70% of those people have Alzheimer’s disease, which is characterized by a loss of brain cells associated with the toxic ...
Compared to those who remained cognitively healthy, people who eventually developed the mind-robbing disease had higher levels of an Alzheimer's-linked protein in their spinal fluid 18 years prior ...
Illustration of how Alzheimer’s Disease spreads through the brain Credit: National Institute on Aging, National Institutes of Health: Date: 17 November 2008, 13:32: Source: Alzheimer’s Disease, Spreads through the Brain: Author: NIH Image Gallery from Bethesda, Maryland, USA: Other versions
Studies have shown that PCA may be a variant of Alzheimer's disease (AD), with an emphasis on visual deficits. [2] [11] Although in primarily different, but sometimes overlapping, brain regions, both involve progressive neural degeneration, as shown by the loss of neurons and synapses, and the presence of neurofibrillary tangles and senile plaques in affected brain regions; this eventually ...
Inflammation is a general marker of tissue damage in any disease, and may be either secondary to tissue damage in Alzheimer's disease or a marker of an immunological response. [146] There is increasing evidence of a strong interaction between the neurons and the immunological mechanisms in the brain.
The hallmark symptom of LATE is a progressive memory loss that predominantly affects short-term and episodic memory. [1] This impairment is often severe enough to interfere with daily functioning and usually remains the chief neurologic deficit, unlike other types of dementia in which non-memory cognitive domains and behavioral changes might be noted earlier or more prominently. [1]
In Alzheimer’s disease, the most common form of dementia, the blood-brain barrier is disrupted. A new study has uncovered unique molecular signatures linked to the disruption of this blood-brain ...
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