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CAS Number. 55-21-0 ... Benzamide is an organic compound with the chemical formula of C 7 H 7 NO. It is the simplest amide derivative of benzoic acid.
Medulloblastoma [20] [21] Advanced solid tumors (including ovarian, breast, pancreatic, stomach, oesophageal cancers and glioblastoma multiforme) [22] [23] [24] Acute leukemia [25] and chronic myeloid leukemia [26] Myelofibrosis and essential thrombocythaemia [27] It has demonstrated significant efficacy against melanoma in vitro and in vivo. [28]
Trimethobenzamide synthesis: Hoffmann La Roche, U.S. patent 2,879,293 (1959). Alkylation of the sodium salt of p-hydroxybenzaldehyde (1) with 2-dimethylaminoethyl chloride affords the ether (2).
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3-Aminobenzamide is an inhibitor of poly ADP ribose polymerase (PARP), an enzyme responsible for DNA repair, transcription control, and programmed cell death. [1] When PARP is activated it rapidly uses up stores of nicotinamide adenine dinucleotide (NAD +) in the cell as it performs DNA repair.
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Metrizamide is a non-ionic iodine-based radiocontrast agent. [1] It is also a density gradient medium for the centrifugation of biological particles. [2]Historically metrizamide replaced iofendylate (trade names: Pantopaque, Myodil) as the contrast agent of choice for myelography (an X-ray study of the spine now largely replaced by MRI).