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Chelation (/ k iː ˈ l eɪ ʃ ən /) is a type of bonding of ions and their molecules to metal ions. It involves the formation or presence of two or more separate coordinate bonds between a polydentate (multiple bonded) ligand and a single central metal atom.
This enhanced stability, called the chelate effect, is usually attributed to effects of entropy, which favors the displacement of many ligands by one polydentate ligand. Related to the chelate effect is the macrocyclic effect. A macrocyclic ligand is any large ligand that at least partially surrounds the central atom and bonds to it, leaving ...
Chelation therapy is a medical procedure that involves the administration of chelating agents to remove heavy metals from the body. [1] Chelation therapy has a long history of use in clinical toxicology [2] and remains in use for some very specific medical treatments, although it is administered under very careful medical supervision due to various inherent risks, including the mobilization of ...
Doctors explain what chelation therapy is, what it treats, health benefits, and risks involved. Here's what to know about chelation therapy.
EDDHA or ethylenediamine-N,N ′-bis(2-hydroxyphenylacetic acid) is a chelating agent.Like EDTA, it binds metal ions as a hexadentate ligand, using two amines, two phenolate centers, and two carboxylates as the six binding sites.
Cross-linking and immunoprecipitation (CLIP, or CLIP-seq) is a method used in molecular biology that combines UV crosslinking with immunoprecipitation in order to identify RNA binding sites of proteins on a transcriptome-wide scale, thereby increasing our understanding of post-transcriptional regulatory networks.
Skills development in biological illustration can involve two-dimensional art, animation, graphic design, and sculpture (such as necessary in custom prosthetics). It is possible to work in biological illustration without a specific degree, but a degree will significantly enhance an illustrator's employment opportunities.
The extensive flexibility of the carboxylate ligands is critical to the coordination of calcium and other metal ions. Due to its properties, it is used in research to chelate Ca 2+, similarly to EGTA and EDTA. There is a range of reported values for the dissociation constant of BAPTA, though 0.2 μM appears consistently. [1]