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Puberty blockers are commonly used to delay puberty in children with precocious puberty, a condition that activates the hypothalamic-pituitary-gonadal axis prematurely and initiates puberty at an inappropriate age. [30] The main goal of treatment is to preserve children's adult height potential. [31]
Precocious puberty on the rise. In the mid-19th century, girls had their first periods — which typically come about two years after they begin to show signs of breasts or pubic hair — at age ...
They have also been used since the 1980s to treat children for whom puberty starts at an unusually early age to allow puberty to begin later. The blockers have been proven to be highly safe and ...
Precocious puberty is when signs of sexual maturity occur earlier than age 8 in a girl and age 9 in a boy. (Photo: Getty Images) (Getty Images/iStockphoto) Every child goes through puberty, but ...
Precocious puberty in girls begins before the age of 8. The youngest mother on record is Lina Medina , who gave birth at the age of either 5 years, 7 months and 17 days [ 11 ] or 6 years 5 months as mentioned in another report.
Nafarelin is used to treat precocious puberty at a dosage of 1,600 to 1,800 μg per day. [2] The 1,600 μg/day dosage is achieved by two sprays (400 μg total) into each nostril in the morning (four sprays, 800 μg total) and two sprays (400 μg total) into each nostril in the evening (four sprays, 800 μg total). [2]
Another study, which was published in 2024, found that the average age that girls had their first periods decreased from 12.5 years old in 1950 to 1969 to 11.9 years old in 2000 to 2005.
The disorder Central Precocious Puberty (CPP) is also known as Progressive Precocious Gonadarche or GnRH-dependent precocious puberty, and it occurs when a child's body initiates puberty earlier than what is normally observed. Individuals with CPP will often experience an early growth spurt because their bones are maturing faster than usual.