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  2. Benzathine benzylpenicillin - Wikipedia

    en.wikipedia.org/wiki/Benzathine_benzylpenicillin

    Benzathine benzylpenicillin, also known as benzathine penicillin G (BPG), is an antibiotic medication useful for the treatment of a number of bacterial infections. [3] Specifically it is used to treat strep throat, diphtheria, syphilis, and yaws. [3] [5] It is also used to prevent rheumatic fever. [5] It is given by injection into a muscle.

  3. Penicillin - Wikipedia

    en.wikipedia.org/wiki/Penicillin

    Therefore, 2 million units (2 megaunits) of penicillin G is 1.2 g. [22] One unit of penicillin V potassium is defined as 0.625 micrograms. Therefore 400,000 units of penicillin V is 250 mg. [23] The use of units to prescribe penicillin is a historical accident and is largely obsolete outside of the US.

  4. Procaine benzylpenicillin - Wikipedia

    en.wikipedia.org/wiki/Procaine_benzylpenicillin

    Specific indications for procaine penicillin include: [6] Syphilis. In the United States, Bicillin C-R (an injectable suspension which 1.2 million units of benzathine penicillin and 1.2 million units of procaine penicillin per 4 ml) is not recommended for treating syphilis, since it contains only half the recommended dose of benzathine penicillin.

  5. Dose (biochemistry) - Wikipedia

    en.wikipedia.org/wiki/Dose_(biochemistry)

    In single-dose scenarios, the patient's body weight and the drug's recommended dose per kilogram are used to determine a safe one-time dose. If multiple doses of treatment are needed in a day, the physician must take into account information regarding the total amount of the drug which is safe to use in one day, and how that should be broken up ...

  6. Management of tuberculosis - Wikipedia

    en.wikipedia.org/wiki/Management_of_tuberculosis

    Day 1: INH at 1/3 or 1/4 dose; Day 2: INH at 1/2 dose; Day 3: INH at full dose; Day 4: RMP at 1/3 or 1/4 dose; Day 5: RMP at 1/2 dose; Day 6: RMP at full dose; Day 7: EMB at 1/3 or 1/4 dose; Day 8: EMB at 1/2 dose; Day 9: EMB at full dose; No more than one test dose per day should be given, and all other drugs should be stopped while test ...

  7. Defined daily dose - Wikipedia

    en.wikipedia.org/wiki/Defined_Daily_Dose

    The dose is based on recommendations for treatment rather than prevention, except if prevention is the main indication. Generally there is only one DDD for all formulations of a drug, however exceptions are made if some formulations are typically used in significantly different strengths (e.g., antibiotic injection in a hospital vs tablets in ...

  8. Beta-lactamase - Wikipedia

    en.wikipedia.org/wiki/Beta-lactamase

    The structure of a Streptomyces serine β-lactamase (SBLs) is given by 1BSG.The alpha-beta fold (InterPro: IPR012338) resembles that of a DD-transpeptidase, from which the enzyme is thought to have evolved. β-lactam antibiotics bind to DD-transpeptidases to inhibit bacterial cell wall biosynthesis.

  9. Modified-release dosage - Wikipedia

    en.wikipedia.org/wiki/Modified-release_dosage

    In this case, a broad therapeutic window is necessary to avoid toxicity; otherwise, the risk is unwarranted and another mode of administration would be recommended. [3] Appropriate half-lives used to apply sustained methods are typically 3–4 hours and a drug dose greater than 0.5 grams is too high. [4] [5]