Search results
Results from the WOW.Com Content Network
[4] [5] [6] According to Pender (1972), "the state has been designated as dissociative anesthesia since the patient truly seems disassociated from his environment." [ 7 ] Both Pender (1970) and Johnstone et al. (1959) reported that patients under anaesthesia due to either ketamine or phencyclidine were prone to purposeless movements and had ...
This page was last edited on 7 December 2018, at 22:49 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; additional terms may apply.
At this time the United States military investigated it along with a wide range of possible nonlethal, psychoactive and psychotomimetic incapacitating agents including psychedelic drugs such as LSD and THC, dissociative drugs such as ketamine and phencyclidine, potent opioids such as fentanyl, as well as several glycolate anticholinergics.
Methoxetamine (MXE) is a dissociative hallucinogen that has been sold as a designer drug. [5] [6] It differs from many dissociatives such as ketamine and phencyclidine (PCP) that were developed as pharmaceutical drugs for use as general anesthetics in that it was designed specifically to increase the antidepressant effects of ketamine.
Diphenidine (1,2-DEP, DPD, DND) is a dissociative anesthetic that has been sold as a designer drug. [ 2 ] [ 3 ] [ 4 ] The synthesis of diphenidine was first reported in 1924, and employed a Bruylants reaction analogous to the one that would later be used to discover phencyclidine in 1956. [ 2 ]
It has also been shown to possess affinity for the dopamine D 1, α 1-adrenergic, α 2-adrenergic, imidazoline-1, and σ 1 receptors. [ 146 ] [ 147 ] [ 152 ] Converging lines of evidence established activation of the σ 1 receptor at concentrations of 50–100 μmol/L. [ 153 ] Its efficacies at the other receptor binding sites are unclear.
2-Fluorodeschloroketamine (also known as 2'-Fl-2-Oxo-PCM, Fluoroketamine and 2-FDCK) is a dissociative anesthetic [1] related to ketamine. Its sale and use as a designer drug has been reported in various countries. [2] [3] [4] It is an analogue of ketamine where the chlorine group has been replaced by fluorine. Due to its recent emergence, the ...
Methoxphenidine (methoxydiphenidine, 2-MeO-Diphenidine, MXP) is a dissociative of the diarylethylamine class that has been sold online as a designer drug. [1] [2] Methoxphenidine was first reported in a 1989 patent where it was tested as a treatment for neurotoxic injury. [3]