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Nitrofurantoin cannot be used to treat infections other than simple cystitis. At the concentrations achieved in urine (>100 μg/mL), nitrofurantoin is a bactericide. It is bacteriostatic against most susceptible organisms at concentrations less than 32 μg/mL. [9] Nitrofurantoin and the quinolone antibiotics are mutually antagonistic in vitro ...
[108] [107] Cephalexin or nitrofurantoin are typically used because they are generally considered safe in pregnancy. [107] A kidney infection during pregnancy may result in preterm birth or pre-eclampsia (a state of high blood pressure and kidney dysfunction during pregnancy that can lead to seizures ). [ 42 ]
Nitrofurantoin — a drug used to treat urinary tract infections [3] Ranbezolid — technically an oxazolidinone antibiotic bearing a nitrofuran group; Antimicrobials. Furaltadone — an antiprotozoal; Furazidine — an antibacterial and antiprotozoal Furaginum — an antibacterial; Furylfuramide — a formerly used food preservative
It is life-threatening in the elderly or those who are immunocompromised. [ 13 ] [ 14 ] The most common treatment is antibiotics and these vary in their adverse effects and their effectiveness. [ 13 ] [ 15 ] Pneumonia is also the leading cause of death in children less than five years of age in low income countries. [ 15 ]
The risk appears to be higher among people older than 60 and those also taking corticosteroids; [27] the risk also may be higher among people who are male, have a pre-existing joint or tendon issue, have kidney disease, or are highly active. [28] Some experts have advised avoidance of fluoroquinolones in athletes. [28]
Sulfonamides (such as sulfanilamide, sulfamethoxazole, and mafenide), thiazolesulfone, methylene blue, and naphthalene should also be avoided by people with G6PD deficiency as they antagonize folate synthesis, as should certain analgesics (such as phenazopyridine and acetanilide) and a few non-sulfa antibiotics (nalidixic acid, nitrofurantoin ...
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flesh eating infections (necrotizing fasciits) is often caused by streptococcus pyogenes or staphylococcus sp. i don't think this is the appropriate forum for a discussion on treatment options, but nitrofurantoin does not get absorbed very well and doesn't penetrate most of the tissues associated with staph infections.