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Phenytoin (PHT), sold under the brand name Dilantin among others, [1] is an anti-seizure medication. [3] It is useful for the prevention of tonic-clonic seizures (also known as grand mal seizures) and focal seizures, but not absence seizures. [3]
The British National Formulary (BNF) is a United Kingdom (UK) pharmaceutical reference book that contains a wide spectrum of information and advice on prescribing and pharmacology, along with specific facts and details about many medicines available on the UK National Health Service (NHS).
Severe side effects may include suicide and psychosis. [ 8 ] [ 7 ] Use during pregnancy may result in harm to the fetus. [ 9 ] Primidone is an anticonvulsant of the barbiturate class; [ 7 ] however, its long-term effect in raising the seizure threshold is likely due to its active metabolite, phenobarbital . [ 10 ]
The plasma half-life is about 35 to 40 hours when carbamazepine is given as single dose, but it is a strong inducer of liver enzymes, and the plasma half-life shortens to about 12 to 17 hours when it is given repeatedly. The half-life can be further shortened to 9–10 hours by other enzyme inducers such as phenytoin or phenobarbital. About 70% ...
Purple glove syndrome is caused by the intravenous anticonvulsant phenytoin. [3] This medication has many already established neurological side effects. However, glove syndrome is a rare, with prevalence ranging from 1.7% to 5.9%, but has very serious adverse effect that may lead to limb amputations.
The Food and Drug Administration (FDA) also recently approved Olumiant, a new treatment for severe alopecia areata. This medication is a Janus kinase (JAK) inhibitor that works by blocking the ...
A leaked video of UnitedHealth CEO Andrew Witty defending claim denials after Brian Thompson’s murder has sparked backlash. Critics argue the policy contributes to medical bankruptcies and lives ...
Fosphenytoin, also known as fosphenytoin sodium, and sold under the brand name Cerebyx among others, is a water-soluble phenytoin prodrug that is administered intravenously to deliver phenytoin, potentially more safely than intravenous phenytoin. It is used in the acute treatment of convulsive status epilepticus.