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  2. HER2 - Wikipedia

    en.wikipedia.org/wiki/HER2

    HER2 is the target of the monoclonal antibody trastuzumab (marketed as Herceptin). Trastuzumab is effective only in cancers where HER2 is over-expressed. One year of trastuzumab therapy is recommended for all patients with HER2-positive breast cancer who are also receiving chemotherapy. [33] Twelve months of trastuzumab therapy is optimal.

  3. ErbB - Wikipedia

    en.wikipedia.org/wiki/ErbB

    Although herceptin works well in most breast cancer cases, it has not been yet elucidated as to why some HER2-positive breast cancers don't respond well. Research suggests that a low FISH test ratio in estrogen receptor positive breast cancers are less likely to respond to this drug. [33]

  4. Invasive carcinoma of no special type - Wikipedia

    en.wikipedia.org/wiki/Invasive_carcinoma_of_no...

    HER2-positive tumors may be treated with the targeted medical therapy (e.g., trastuzumab). Further information: Breast cancer management and Breast cancer § Management Treatment of non-metastatic invasive breast cancer can vary based on staging, usually early stage (stages I and II) versus locally advanced (stage III).

  5. Endocrine therapy resistance in breast cancer - Wikipedia

    en.wikipedia.org/wiki/Endocrine_therapy...

    Luminal A (ER and/or PR positive; HER2 negative) Luminal B (ER and/or PR positive; HER2 positive) HER2-enriched (ER/PR negative; HER2 positive) Basal like (triple negative). [6] Additionally, cancers can be ER-/PR+ or ER+/PR-, but these are unnamed and relatively rare. [7] The receptor status of a cancer is assessed for all breast cancers as it ...

  6. Breast cancer - Wikipedia

    en.wikipedia.org/wiki/Breast_cancer

    This is an accepted version of this page This is the latest accepted revision, reviewed on 14 January 2025. Cancer that originates in mammary glands Medical condition Breast cancer An illustration of breast cancer Specialty Surgical Oncology Symptoms A lump in a breast, a change in breast shape, dimpling of the skin, fluid from the nipple, a newly inverted nipple, a red scaly patch of skin on ...

  7. Estrogen receptor test - Wikipedia

    en.wikipedia.org/wiki/Estrogen_receptor_test

    The ER can serve as an indicative biomarker as it is a potential predictor for the clinical responses of a patient to certain treatments. Patients with breast cancer that is ER-positive at presentation are most likely to respond to cancer treatments through endocrine therapy. [9]

  8. Breast cancer management - Wikipedia

    en.wikipedia.org/wiki/Breast_cancer_management

    Staging breast cancer is the initial step to help physicians determine the most appropriate course of treatment. As of 2016, guidelines incorporated biologic factors, such as tumor grade, cellular proliferation rate, estrogen and progesterone receptor expression, human epidermal growth factor 2 (HER2) expression, and gene expression profiling into the staging system.

  9. Patient derived xenograft - Wikipedia

    en.wikipedia.org/wiki/Patient_derived_xenograft

    The classification of genetic breast cancer subtypes, including triple-negative and HER2-positive subtypes, [8] have allowed oncologists to use a patient’s breast cancer subtype to personalize cancer therapy schedules.

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