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Lamotrigine, sold under the brand name Lamictal among others, is a medication used to treat epilepsy and stabilize mood in bipolar disorder. [ 5 ] [ 8 ] For epilepsy, this includes focal seizures , tonic-clonic seizures , and seizures in Lennox-Gastaut syndrome . [ 8 ]
Valproate (valproic acid, VPA, sodium valproate, and valproate semisodium forms) are medications primarily used to treat epilepsy and bipolar disorder and prevent migraine headaches. [7] They are useful for the prevention of seizures in those with absence seizures , partial seizures , and generalized seizures . [ 7 ]
Valproate – Available in extended release form. This drug can be very irritating to the stomach, especially when taken as a free acid. Liver function and CBC should be monitored. [6] Lamotrigine (aka Lamictal) – FDA approved for bipolar disorder maintenance therapy, not for acute mood problems like depression or mania/hypomania. [7]
Among bipolar patients taking anticonvulsants, those on lamotrigine have a better cognitive profile than those on carbamazepine, valproate, topiramate, and zonisamide. [36] Although decreased verbal memory and slowed psychomotor speed are common side effects of lithium use [37] [38] these side effects usually disappear after discontinuation of ...
Depakote (valproic acid/sodium valproate) – an antiepileptic and mood stabilizer used to treat bipolar disorder, neuropathic pain and others; sometimes called an antimanic medication. Depakene is the trade name for the same drug prepared without sodium. Desyrel – an atypical antidepressant used to treat depression and insomnia
In pharmacology, a GABA transaminase inhibitor is an enzyme inhibitor that acts upon GABA transaminase. [1] Inhibition of GABA transaminase enzymes reduces the degradation of GABA, leading to increased neuronal GABA concentrations.
Combining lamotrigine with sodium valproate increases the risk of SJS. [26] Nonsteroidal anti-inflammatory drugs (NSAIDs) are a rare cause of SJS in adults; the risk is higher for older patients, women, and those initiating treatment. [27] Typically, the symptoms of drug-induced SJS arise within a week of starting the medication.
ATC code N03 Antiepileptics is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products.
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