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Dental cavity vaccines directed to key components of S. mutans colonization and enhanced by safe and effective adjuvants and optimal delivery vehicles, are likely to be forthcoming. Some believe that the rational target for developing an anti-caries vaccine is a protein antigen, which has adherent functional and important immunogenic regions.
Streptococcus mutans is a facultatively anaerobic, gram-positive coccus (round bacterium) commonly found in the human oral cavity and is a significant contributor to tooth decay. [ 1 ] [ 2 ] The microbe was first described by James Kilian Clarke in 1924.
Progression and build-up of dental plaque can give rise to tooth decay – the localised destruction of the tissues of the tooth by acid produced from the bacterial degradation of fermentable sugar – and periodontal problems such as gingivitis and periodontitis; [3] hence it is important to disrupt the mass of bacteria and remove it. [4]
Dental caries: Under research [7] Bartonella bacilliformis: Carrion's disease: Peripheral blood smear with Giemsa stain, Columbia blood agar cultures, immunoblot, indirect immunofluorescence, and PCR: Fluoroquinolones (such as ciprofloxacin) or chloramphenicol in adults and chloramphenicol plus beta-lactams in children No Bartonella henselae ...
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Early childhood caries (ECC) is a multifactorial disease, with risk factors including but not limited to, cariogenic bacteria, diet practices and socioeconomic factors. [6] Deciduous teeth begin to erupt at 6 months of age, once visible in the oral cavity they are susceptible to tooth decay or dental caries. [1]
Live recombinant vaccines can be administered via orally or nasally, instead of injection. Common examples of vaccines with the aforementioned route of admission include the oral polio vaccine and the nasal spray influenza vaccine. [3] [4] These vaccines can stimulate mucosal immunity and eliminate adverse effects associated with injection. [5]
Tooth decay (dental caries) is one of the most prevalent chronic diseases worldwide. [30] Although it is rarely life-threatening, tooth decay can cause pain and impair eating, speaking, facial appearance, and acceptance into society, [31] and it greatly affects the quality of life of children, particularly those of low socioeconomic status. [30]