Search results
Results from the WOW.Com Content Network
Scaffolding is a technique used in bioinformatics. It is defined as follows: [ 1 ] Link together a non-contiguous series of genomic sequences into a scaffold, consisting of sequences separated by gaps of known length.
the dynamic properties of S/MAR-scaffold contacts as derived by haloFISH investigations [5] the fact that during transcription DNA is reeled through RNA-polymerase which itself is a fixed component of the nuclear matrix [6] the fact that certain domain-intrinsic S/MARs require the support of an adjacent transcription factor to become active. [4]
In computational biology, N50 and L50 are statistics of a set of contig or scaffold lengths. The N50 is similar to a mean or median of lengths, but has greater weight given to the longer contigs. It is used widely in genome assembly, especially in reference to contig lengths within a draft assembly.
Eukaryotic DNA replication is a conserved mechanism that restricts DNA ... it serves as a scaffold for the assembly of other key initiation factors of the ...
In biology, the chromosome scaffold is the backbone that supports the structure of the chromosomes. It is composed of a group of non-histone proteins that are essential in the structure and maintenance of eukaryotic chromosomes throughout the cell cycle. These scaffold proteins are responsible for the condensation of chromatin during mitosis. [1]
This particular function is considered a scaffold's most basic function. Scaffolds assemble signaling components of a cascade into complexes. This assembly may be able to enhance signaling specificity by preventing unnecessary interactions between signaling proteins, and enhance signaling efficiency by increasing the proximity and effective concentration of components in the scaffold complex.
S/MARs (scaffold/matrix attachment regions), the DNA regions that are known to attach genomic DNA to variety of nuclear proteins, show an ever increasing spectrum of established biological activities. There is a known overlap of this large group of sequences with sequences termed LADs (lamina attachment domains).
A contig (from contiguous) is a set of overlapping DNA segments that together represent a consensus region of DNA. [1] In bottom-up sequencing projects, a contig refers to overlapping sequence data (); [2] in top-down sequencing projects, contig refers to the overlapping clones that form a physical map of the genome that is used to guide sequencing and assembly. [3]