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DNA nanotechnology is the design and manufacture of artificial nucleic acid structures for technological uses. In this field, nucleic acids are used as non-biological engineering materials for nanotechnology rather than as the carriers of genetic information in living cells.
Nano-scaffolding or nanoscaffolding is a medical process used to regrow tissue and bone, including limbs and organs. The nano-scaffold is a three-dimensional structure composed of polymer fibers very small that are scaled from a Nanometer (10 −9 m) scale. [ 1 ]
This is an example of a scaffold. Scaffolding is a technique used in bioinformatics. It is defined as follows: [1] Link together a non-contiguous series of genomic sequences into a scaffold, consisting of sequences separated by gaps of known length. The sequences that are linked are typically contiguous sequences corresponding to read overlaps.
The method of DNA origami was developed by Paul Rothemund at the California Institute of Technology. [6] In contrast to common top-down fabrication methods such as 3D printing or lithography which involve depositing or removing material through a tool, DNA Nanotechnology, as well as DNA Origami as a subset, is a bottom-up fabrication method.
In 2006, Paul Rothemund made a breakthrough in DNA nanotechnology, developing the DNA origami. His DNA origami took a long, single-stranded DNA molecule (referred to as the "scaffold") and folded it into short, single-stranded DNA oligonucleotides (referred to as "staples").
This glossary of nanotechnology is a list of definitions of terms and concepts relevant to nanotechnology, its sub-disciplines, and related fields. For more inclusive glossaries concerning related fields of science and technology, see Glossary of chemistry terms , Glossary of physics , Glossary of biology , and Glossary of engineering .
Schematic illustration of a MSP nanodisc with a 7-transmembrane protein embedded. Diameter is about 10 nm. Picture from Sligar Lab. A nanodisc is a synthetic model membrane system which assists in the study of membrane proteins. [1]
the dynamic properties of S/MAR-scaffold contacts as derived by haloFISH investigations [5] the fact that during transcription DNA is reeled through RNA-polymerase which itself is a fixed component of the nuclear matrix [6] the fact that certain domain-intrinsic S/MARs require the support of an adjacent transcription factor to become active. [4]