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The term variant of concern (VOC) for SARS-CoV-2, which causes COVID-19, is a category used for variants of the virus where mutations in their spike protein receptor binding domain (RBD) substantially increase binding affinity (e.g., N501Y) in RBD-hACE2 complex (genetic data), while also being linked to rapid spread in human populations ...
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“Variants that can infect people better or evade immunity to the last variant are more likely to cause a new COVID wave,” Peter Kasson, M.D., Ph.D., B.S., of the University of Virginia’s ...
Distinct from the PANGOLIN tool, Pango lineages are regularly, manually curated based on the current globally circulating diversity. A large phylogenetic tree is constructed from an alignment containing publicly available SARS-CoV-2 genomes, and sub-clusters of sequences in this tree are manually examined and cross-referenced against epidemiological information to designate new lineages; these ...
FLiRT variants are subvariants of omicron and were responsible for most COVID-19 cases in the U.S. by the beginning of July 2024. The KP.1 and KP.2 strains of FLiRT are the dominant strains of the ...
The Omicron variant features as such for the first time in the overview of WHO's weekly operational update, namely "Supporting Omicron variant detection and COVID-19 response in southern Africa." As of 2 December, Botswana and South Africa have reported 19 and 172 Omicron variant cases, respectively, accounting for 62% of global cases.
False-colour transmission electron micrograph of a B.1.1.7 variant coronavirus. The variant's increased transmissibility is believed to be due to changes in the structure of the spike proteins, shown here in green. There are many thousands of variants of SARS-CoV-2, which can be grouped into the much larger clades. [142]
In week 8, the variant was found to have a dominant share of 56.4% (758/1345) according to the interpretable results of a weekly genome sequencing survey comprising 0.9% of all COVID-19 positive tests, or 59.5% according to a variant-specific RT-PCR survey testing 54% of all the COVID-19 positive tests. [124]
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