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A study conducted by the pharmaceutical company Smith, Kline & French (SKF) in 1947 showed that amphetamine can affect the brain center for appetite and help to reduce weight. In the late 1960s, weight reduction was the most common indication for ATS. [5] Nowadays, to suppress appetite, phentermine is still used. [2]
Amphetamine is a weak base with a pK a of 9.9; [3] consequently, when the pH is basic, more of the drug is in its lipid soluble free base form, and more is absorbed through the lipid-rich cell membranes of the gut epithelium. [3] [29] Conversely, an acidic pH means the drug is predominantly in a water-soluble cationic (salt) form, and less is ...
Chlorphentermine, sold under the brand names Apsedon, Desopimon, and Lucofen, is a serotonergic appetite suppressant of the amphetamine family. Developed in 1962, it is the para-chloro derivative of the better-known appetite suppressant phentermine, which is still in current use. The drug acts as a highly selective serotonin releasing agent ...
In 1959, phentermine first received approval from the US Food and Drug Administration (FDA) as an appetite suppressant. [43] Eventually a hydrochloride salt and a resin form became available. [43] Phentermine was marketed with fenfluramine or dexfenfluramine as a combination appetite suppressant and fat burning agent under the popular name fen ...
The drug's main function is to reduce appetite, which in turn reduces caloric intake. [ medical citation needed ] Although the mechanism of action of the sympathomimetic appetite suppressants in the treatment of obesity is not fully known, these medications have pharmacological effects similar to those of amphetamines.
The good news is that there are plenty of healthy and effective ways to suppress your appetite for weight loss without resorting to extreme measures. From simple lifestyle changes to smart food ...
An anorectic is a drug which reduces appetite, resulting in lower food consumption, leading to weight loss. [1] These substances work by affecting the central nervous system or certain neurotransmitters to create a feeling of fullness or reduce the desire to eat.
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