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  2. Interferon-stimulated gene - Wikipedia

    en.wikipedia.org/wiki/Interferon-stimulated_gene

    ISGs are genes whose expression can be stimulated by interferon, but may also be stimulated by other pathways. [1] Interferons are a type of protein called a cytokine, which is produced in response to infection. [9] When released, they signal to infected cells and other nearby cells that a pathogen is present. [9]

  3. ISG15 - Wikipedia

    en.wikipedia.org/wiki/ISG15

    Interferon-stimulated gene 15 (ISG15) is a 17 kDa secreted protein that in humans is encoded by the ISG15 gene. [ 5 ] [ 6 ] ISG15 is induced by type I interferon (IFN) and serves many functions, acting both as an extracellular cytokine and an intracellular protein modifier.

  4. Interferome - Wikipedia

    en.wikipedia.org/wiki/Interferome

    Interferome is an online bioinformatics database of interferon-regulated genes (IRGs). [1] These Interferon Regulated Genes are also known as Interferon Stimulated Genes (ISGs). The database contains information on type I (IFN alpha, beta), type II (IFN gamma) and type III (IFN lambda) regulated genes and is regularly updated.

  5. Stimulator of interferon genes - Wikipedia

    en.wikipedia.org/wiki/Stimulator_of_interferon_genes

    Upon activation, STING stimulates TBK1 activity to phosphorylate IRF3 or STAT6. Phosphorylated IRF3s and STAT6s dimerize, and then enter nucleus to stimulate expression of genes involved in host immune response, such as IFNB, CCL2, CCL20, etc. [8] [23] Several reports suggested that STING is associated with the activation of selective autophagy ...

  6. Interferon - Wikipedia

    en.wikipedia.org/wiki/Interferon

    It took another fifteen to twenty years, using somatic cell genetics, to show that the interferon action gene and interferon gene reside in different human chromosomes. [71] [72] [73] The purification of human beta interferon did not occur until 1977. Y.H. Tan and his co-workers purified and produced biologically active, radio-labeled human ...

  7. IFIT3 - Wikipedia

    en.wikipedia.org/wiki/IFIT3

    Interferon-induced protein with tetratricopeptide repeats 3, also known as interferon-stimulated gene 49 ... is a protein that in humans is encoded by the IFIT3 gene. ...

  8. IFNA2 - Wikipedia

    en.wikipedia.org/wiki/IFNA2

    The gene encoding IFNα2, the IFNA2 gene, is clustered with all other type I IFN genes on chromosome 9 [8] and as all type I IFN genes, it is devoid of intron. [9] The open reading frame (coding sequence) of IFNA2 codes for a pre-protein of 188 amino acids with a 23 amino acid signal peptide allowing secretion of the mature protein.

  9. Enhanceosome - Wikipedia

    en.wikipedia.org/wiki/Enhanceosome

    The best known example of the enhanceosome acts on the human interferon-beta gene, which is upregulated in cells that are infected by viruses. [5] Three activator proteins— NF-κB , an interferon activator protein such as IRF-3 , and the ATF -2/c-Jun complex—cooperatively bind to the upstream enhancer region upon viral infection.

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