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Cutaneous leishmaniasis is the most common form of leishmaniasis affecting humans. [4] ... In addition, the effects of leishmaniasis treatment in children, women of ...
The evidence around the treatment of cutaneous leishmaniasis is poor. [3] Several topical treatments may be used for cutaneous leishmaniasis. Which treatments are effective depends on the strain, with topical paromomycin effective for L. major, L. tropica, L. mexicana, L. panamensis, and L. braziliensis. [11]
Sodium stibogluconate, sold under the brand name Pentostam among others, is a medication used to treat leishmaniasis. [3] This includes leishmaniasis of the cutaneous, visceral, and mucosal types. [4] Some combination of miltefosine, paromomycin and liposomal amphotericin B, however, may be recommended due to issues with resistance.
Miltefosine, sold under the trade name Impavido among others, is a medication mainly used to treat leishmaniasis and free-living amoeba infections such as Naegleria fowleri and Balamuthia mandrillaris. [4] This includes the three forms of leishmaniasis: cutaneous, visceral and mucosal. [5] It may be used with liposomal amphotericin B or ...
The first pentavalent antimonial, urea stibamine, was synthesised by the Indian scientist Upendranath Brahmachari in 1922. Though it caused a dramatic decline in deaths due to leishmaniasis, it fell out of favour in the 1950s due to higher toxicity compared to sodium stibogluconate.
L. tropica causes a broad spectrum of leishmaniasis forms in humans. Most common is a variant called dry-type cutaneous leishmaniasis. After an incubation period lasting more than 2 months, a small brownish nodular lesion will appear with a slowly extending plaque reaching a size of 1–2 centimetres (0.39–0.79 in) after 6 months.
Leishmania major is a species of parasite found in the genus Leishmania, and is associated with the disease zoonotic cutaneous leishmaniasis (also known as Aleppo boil, Baghdad boil, Bay sore, Biskra button, Chiclero ulcer, Delhi boil, Kandahar sore, Lahore sore, Oriental sore, Pian bois, and Uta). [1]
In Brazil, currently, the most common treatment for humans to cure leishmaniasis is the drug meglumine antimoniate. [3] About 80 percent of patients with cutaneous leishmaniasis respond successfully to the drug, but for disseminated leishmaniasis only 40 percent are successfully cured of the disease after one treatment, so in these cases the ...