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Increased serum and urine levels of hydroxyproline have also been demonstrated in Paget's disease. [10] Mass spectrometry analysis showed decreased amount of hydroxyproline post-translational modifications in non inflamed tissue from ulcerative colitis patients when compared to tissue from donors without the disease. [11]
An elevated level of alkaline phosphatase in the blood in combination with normal calcium, phosphate, and aminotransferase levels in an elderly patient are suggestive of Paget's disease. Markers of bone turnover in urine eg. Pyridinoline; Elevated levels of serum and urinary hydroxyproline are also found.
Hyperprolinemia type II results in proline levels in the blood between 10 and 15 times higher than normal, and high levels of a related compound called pyrroline-5-carboxylate. This rare form of the disorder may appear benign at times, [ 2 ] but often involves seizures, convulsions, and intellectual disability.
In contrast, optimal (health) range or therapeutic target is a reference range or limit that is based on concentrations or levels that are associated with optimal health or minimal risk of related complications and diseases. For most substances presented, the optimal levels are the ones normally found in the population as well.
The brain may contain higher -- and more significant -- amounts of microplastics than other organs in the body, according to a new study. Researchers from the University of New Mexico Health ...
Proline oxidase, or proline dehydrogenase, functions as the initiator of the proline cycle. Proline metabolism is especially important in nutrient stress because proline is readily available from the breakdown of extracellular matrix (ECM), and the degradation of proline through the proline cycle initiated by proline oxidase (PRODH), a mitochondrial inner membrane enzyme, can generate ATP.
Managing cholesterol levels. Staying on top of your vision health. On the exercise front, it’s clear that working out—and even going hard for a few minutes here and there—can pay off big ...
During the week ending Feb. 1, nearly 8% of visits to health care providers were for influenza-like illness (a fever plus a cough or sore throat) — the highest level seen since the peak of the ...