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Evolocumab, [6] sold under the brand name Repatha, is a monoclonal antibody that is an immunotherapy medication for the treatment of hyperlipidemia. Evolocumab is a fully human monoclonal antibody that inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9) .
Repatha is a brand name for the injectable drug evolocumab. Repatha treats high cholesterol and reduces the risk of heart attack , stroke, and certain types of heart surgery in adults with ...
Neurogenic bowel dysfunction (NBD) is reduced ability or inability to control defecation due to deterioration of or injury to the nervous system, resulting in fecal incontinence or constipation. [1] It is common in people with spinal cord injury (SCI), multiple sclerosis (MS) or spina bifida .
The ODS may or may not co-exist with other functional bowel disorders, such as slow transit constipation or irritable bowel syndrome. [20] Of all cases of primary constipation, it is reported that 58% are dyssynergic defecation, 47% are slow transit constipation and 58% are irritable bowel syndrome. [ 22 ]
Pseudo-obstruction in adults is a rare disorder that can have primary or secondary causes. Adult pseudo-obstruction's most frequent secondary causes include radiation enteritis, amyloidosis, paraneoplastic syndromes, hypothyroidism, usage of substances with anticholinergic or narcotic effects, diabetes, scleroderma, and other connective tissue ...
Functional abdominal pain syndrome is a functional gastrointestinal disorder. [4] Functional gastrointestinal disorders (FGD) are common medical conditions characterized by recurrent and persistent gastrointestinal symptoms caused by improper functioning of the enteric system in the absence of any identifiable organic or structural pathology, such as ulcers, inflammation, tumors or masses.
Causes: Idiopathic, Kawasaki disease, Parkinson's disease, Chagas disease, Hirschsprung's disease, intestinal hypogangliosis, collagen vascular disease, mitochondrial disease, endocrine disorders, medication side effects: Diagnostic method: Signs and symptoms consistent with a mechanical intestinal obstruction with no identifying lesion.
Constipation is a bowel dysfunction that makes bowel movements infrequent or hard to pass. [2] The stool is often hard and dry. [4] Other symptoms may include abdominal pain, bloating, and feeling as if one has not completely passed the bowel movement. [3]