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Prazosin, sold under the brand name Minipress among others, is a medication used to treat high blood pressure, symptoms of an enlarged prostate, and nightmares related to post-traumatic stress disorder (PTSD). [6] It is an α 1 blocker. [6] It is a less preferred treatment of high blood pressure. [6] Other uses may include heart failure and ...
Prazosin (Minipress) for nightmares: prazosin is approved for the use of hypertension. A 2012 systematic review showed a small benefit for the treatment of PTSD-associated night terrors. Other non-FDA-approved uses for prazosin include the treatment of Raynaud's disease and poisoning due to scorpion venom.
The nightmares usually occur during the REM stage of sleep, and the person who experiences the nightmares typically remembers them well upon waking. [2] More specifically, nightmare disorder is a type of parasomnia , a subset of sleep disorders categorized by abnormal movement or behavior or verbal actions during sleep or shortly before or after.
Prazosin is commonly used as an antihypertensive, but because alpha-1-adrenergic activity has been connected to fear and startle responses, it sees use as a PTSD treatment. [19] [20] Prazosin has been established as an effective and safe centrally active alpha-1-adrenergic receptor antagonist. It can be used to treat trauma-related nightmares ...
High doses of the α 1 blocker, prazosin, have been efficacious in treating patients with PTSD induced nightmares due to its ability to block the effects of norepinephrine. [27] Adverse effects of prazosin to treat PTSD nightmares include dizziness, first dose effect (a sudden loss of consciousness), weakness, nausea, and fatigue. [27]
Prazosin (alpha-1 blocker) appears useful in decreasing the number of nightmares and the distress caused by them in people with PTSD. [ 28 ] [ 29 ] Risperidone (atypical antipsychotic) at a dosage of 2 mg per day, has been shown in a case report to lead to the remission of nightmares on the first night.
Prazosin: Selective alpha-1 blocker: Hypertension, benign prostatic hyperplasia, PTSD associated nightmares and Raynaud phenomenon [28] APO-PRAZO [29] Tamsulosin: Selective alpha-1 blocker: Benign prostatic hypertrophy [30] HARNAL D [31] Yohimbine: Selective alpha-2 blocker: Not used clinically, but available for treatment of male erectile ...
Common examples of alpha 1 blockers are Tamsulosin, Prazosin, Phentolamine, and Phenoxybenzamine. [1] Each agent has its own off-label uses, some examples include Tamsulosin for urinary disorders, Prazosin for post-traumatic stress disorder -related nightmares and Raynaud phenomenon , Phentolamine for hypertensive crisis and extravasation of ...