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Spironolactone is an acne treatment prescribed by dermatologists. Find out how spironolactone improves the appearance of hormonal acne, side effects, and more. Everything I Wish I Knew About ...
For acne, the dosage is higher: it’s often started at 50 mg and then titrated up to 100 mg, and in some cases, 200 mg. Those dosages haven’t been studied in large, long-term clinical trials.
[145] [146] [147] However, a 2017 hybrid systematic review found that the incidence of depression in women treated with spironolactone for acne was less than 1%. [64] Likewise, a 10-year observational study found that the incidence of depression in 196 transgender women taking high-dose spironolactone in combination with an estrogen was less ...
In a 2018 survey of 1,013 people, the following percentages of women reported having acne: Almost 5 percent of women ages 20 through 29. 35 percent of women ages 30 through 39. 26 percent of women ...
[37] [106] Alone or in combination with a birth control pill, spironolactone has shown a 33 to 85% reduction in acne lesions in women. [117] The effectiveness of spironolactone for acne appears to be dose-dependent. [117] High-dose cyproterone acetate alone reportedly decreases acne symptoms in women by 75 to 90% within three months. [128]
Side effects of spironolactone in clinical studies for acne in women Side effect RCTs Tooltip Randomized controlled trials (n (ITT Tooltip Intention-to-treat analysis) = 326) Case series (n (ITT Tooltip Intention-to-treat analysis) = 663) Number % Number % Menstrual irregularities: 38: 13.4 (of 283) 216: 33.4 (of 646) Breast tenderness: 8: 2.5: ...
Additionally, topical retinoids can help manage chin acne, Dr. Kobets says. Adapalene (like Differin or La-Roche Posay Effaclar), an over-the-counter retinoid for acne, essentially puts your skin ...
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