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Biguanide (/ b aɪ ˈ ɡ w ɒ n aɪ d /) is the organic compound with the formula HN(C(NH)NH 2) 2. It is a colorless solid that dissolves in water to give a highly basic solution. It is a colorless solid that dissolves in water to give a highly basic solution.
The high levels of testosterone in males are why hematocrit and hemoglobin levels are higher in men than in women. [125] Due to stimulation of erythropoiesis, anabolic–androgenic steroids (AAS) such as oxymetholone and nandrolone decanoate are effective for and used in the treatment of severe anemia (very low hematocrit).
Reproductive toxicity refers to the potential risk from a given chemical, physical or biologic agent to adversely affect both male and female fertility as well as offspring development. [1] Reproductive toxicants may adversely affect sexual function, ovarian failure, fertility as well as causing developmental toxicity in the offspring.
Renal toxicity, animal carcinogenicity. [3] Bezitramide: 2004 Netherlands Risk of fatal overdose [10] Bithionol: 1967 US Dermatologic toxicity. [3] Brotizolam: 1989 UK Animal carcinogenicity. [3] Bromfenac: 1998 US Severe hepatitis and liver failure (requiring transplantation). [2] Bucetin: 1986 Germany Kidney damage [3] Buformin: 1978 Germany ...
Phenformin is an antidiabetic drug from the biguanide class. It was marketed as DBI by Ciba-Geigy, but was withdrawn from most markets in the late 1970s due to a high risk of lactic acidosis, which was fatal in 50% of cases. Phenformin was developed in 1957 by Ungar, Freedman and Seymour Shapiro, working for the U.S. Vitamin Corporation ...
[27] [163] Dosages of up to 600 mg/day have been well tolerated in clinical trials, [164] and it is notable that there is a saturation of absorption with bicalutamide such that circulating levels of its active (R)-enantiomer do not further increase above a dosage of 300 mg/day.
Levels of cadmium, a carcinogen at high levels, ranged from 0.29 to 14.12 mcg, with the limit being 4.1 mcg per day. None of the products exceeded the maximum level for arsenic.
The lactic acidosis occurred only in patients with a buformin plasma level of greater than 0.60 μg/mL and was rare in patients with normal renal function. [19] [20] [21] In one report, the toxic oral dose was 329 ± 30 mg/day in 24 patients who developed lactic acidosis on buformin.