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It was discovered to be part of the virus that caused serum hepatitis by virologist Alfred Prince in 1968. Heptavax, a "first-generation" hepatitis B vaccine in the 1980s, was made from HBsAg extracted from the blood plasma of hepatitis patients. More modern vaccines are made from recombinant HBsAg grown in yeast.
HBeAg is a hepatitis B viral protein, produced by the HBcAg reading frame. It is an indicator of active viral replication ; this means the person infected with Hepatitis B can likely transmit the virus on to another person (i.e. the person is infectious).
The hepatitis B vaccine was the first vaccine capable of preventing cancer, specifically liver cancer. [73] Most vaccines are given in three doses over a course of days. A protective response to the vaccine is defined as an anti-HBs antibody concentration of at least 10 mIU/ml in the recipient's serum.
HBsAg (hepatitis B surface antigen) was the first hepatitis B virus protein to be discovered. [15] It consists of small (S), medium (M) and large (L) protein. [16] HBcAg (hepatitis B core antigen) is the main structural protein of HBV icosahedral nucleocapsid and it has function in replication of the virus. [17]
The recombinant vaccine is based on Hepatitis B surface antigen gene inserted into yeast (Saccharomyces cerevisiae) cells which are free of any concerns associated with human blood products. [ 17 ] [ 65 ] This allows the yeast to produce only the noninfectious surface protein, without any danger of introducing actual viral DNA into the final ...
HBcAg (core antigen) is a hepatitis B viral protein. [ 1 ] [ 2 ] It is an indicator of active viral replication; this means the person infected with Hepatitis B can likely transmit the virus on to another person (i.e. the person is infectious).
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