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A Lindlar catalyst is a heterogeneous catalyst consisting of palladium deposited on calcium carbonate or barium sulfate then poisoned with various forms of lead or sulfur. It is used for the hydrogenation of alkynes to alkenes (i.e. without further reduction into alkanes). It is named after its inventor Herbert Lindlar, who discovered it in 1952.
Alkyne metathesis can be used in ring-closing operations and RCAM stands for ring closing alkyne metathesis. The olfactory molecule civetone can be synthesised from a di-alkyne. After ring closure the new triple bond is stereoselectively reduced with hydrogen and the Lindlar catalyst in order to obtain the Z -alkene (cyclic E -alkenes are ...
In many cases, highly empirical modifications involve selective "poisons". Thus, a carefully chosen catalyst can be used to hydrogenate some functional groups without affecting others, such as the hydrogenation of alkenes without touching aromatic rings, or the selective hydrogenation of alkynes to alkenes using Lindlar's catalyst.
The compound was first synthesised by Franz Sondheimer. [6] The original synthesis started by Eglinton reaction of di-alkyne 1,5-hexadiyne with copper(II) acetate in pyridine to give the trimer, followed by deprotonation and isomerization with potassium tert-butoxide in tert-butanol and was concluded with hydrogen organic reduction with Lindlar catalyst.
The largest scale application of this technology is the conversion of acetylene to ethylene in refineries (the steam cracking of alkanes yields a few percent acetylene, which is selectively hydrogenated in the presence of a palladium/silver catalyst). For more complex alkynes, the Lindlar catalyst is widely recommended to avoid formation of the ...
Alkyne trimerisation; ... Birch reduction; Bischler–Möhlau indole synthesis; ... Lindlar catalyst; Lobry de Bruyn–Van Ekenstein transformation;
Reduction of alkynes is a useful method for the stereoselective synthesis of disubstituted alkenes. If the cis -alkene is desired, hydrogenation in the presence of Lindlar's catalyst (a heterogeneous catalyst that consists of palladium deposited on calcium carbonate and treated with various forms of lead) is commonly used, though hydroboration ...
The Lindlar catalyst then reduced the alkyne to the alkene in 1.4 and Swern oxidation converted the alcohol group to the enone group in 1.5. Fragment C11-C15-C16-C17 1.6 was then added as the lithium enolate of isobutyric acid ethyl ester in a conjugate addition to gamma keto ester 1.7.
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