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2. 5-Hydroxytryptophan - Wikipedia

   en.wikipedia.org/wiki/5-Hydroxytryptophan

   5-HTP is produced from the amino acid tryptophan through the action of the enzyme tryptophan hydroxylase. Tryptophan hydroxylase is one of the biopterin-dependent aromatic amino acid hydroxylases. Production of 5-HTP is the rate-limiting step in 5-HT (serotonin) synthesis. 5-HTP is normally rapidly converted to 5-HT by amino acid decarboxylase. [1]

3. Oxitriptan - Wikipedia

   en.wikipedia.org/wiki/Oxitriptan

   5-HTP is rapidly absorbed with a t max of ≈1.5 h, and rapidly eliminated with a half-life of ≈1.5 – 2 h. Co-administration of a decarboxylase inhibitor (e.g., carbidopa, benserazide ) doubles the half-life of 5-HTP to ≈ 3 – 4 h , [ 37 ] [ 34 ] and enhances exposure several-fold, depending on the dosing regimen.

4. Transdermal patch - Wikipedia

   en.wikipedia.org/wiki/Transdermal_patch

   A 21mg dose Nicoderm CQ patch applied to the left arm Contraceptive patch Clonidine tablets and transdermal patch A transdermal patch which delivers medication is applied to the skin in a medical setting. The patch is labelled with the time and date of administration as well as the administrator's initials. Microneedle patch size comparison [1]

5. Melatonin - Wikipedia

   en.wikipedia.org/wiki/Melatonin

   The initial step in the melatonin biosynthesis pathway is the hydroxylation of L-tryptophan's indole ring by the enzyme tryptophan hydroxylase, resulting in the formation of 5-hydroxytryptophan (5-HTP). Subsequently, 5-HTP undergoes decarboxylation, facilitated by pyridoxal phosphate and the enzyme 5-hydroxytryptophan decarboxylase, yielding ...

6. Modified-release dosage - Wikipedia

   en.wikipedia.org/wiki/Modified-release_dosage

   For example, orally administered extended-release morphine can enable certain chronic pain patients to take only 1–2 tablets per day, rather than needing to redose every 4–6 hours as is typical with standard-release morphine tablets. Most commonly it refers to time-dependent release in oral dose formulations. Timed release has several ...

7. Carbidopa - Wikipedia

   en.wikipedia.org/wiki/Carbidopa

   Carbidopa is also used in combination with 5-hydroxytryptophan (5-HTP), a naturally occurring amino acid which is a precursor to the neurotransmitter serotonin and an intermediate in tryptophan metabolism. Carbidopa, which is used in PD to prevent conversion of the levodopa to dopamine, prevents the metabolism of 5-HTP in the liver and causes ...