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Ephedrine promotes modest short-term weight loss, [24] specifically fat loss, but its long-term effects are unknown. [25] In mice, ephedrine is known to stimulate thermogenesis in the brown adipose tissue, but because adult humans have only small amounts of brown fat, thermogenesis is assumed to take place mostly in the skeletal muscle.
In January 2002, Health Canada issued a voluntary recall of all ephedrine products containing more than 8 mg per dose, all combinations of ephedrine with other stimulants such as caffeine, and all ephedrine products marketed for weight-loss or bodybuilding indications, citing a serious risk to health. [2]
This study found that ephedra promoted modest short-term weight loss, but there was insufficient data to determine whether it was effective for long-term weight loss or performance enhancement. The use of ephedrine alkaloids in this study was associated with significant gastrointestinal, psychiatric, and autonomic side effects. [36]
For weight loss, weight management, and overall wellness, focus on eating healthy foods, like high-protein meals, legumes, whole fruits, low-starch veggies, low-fat dairy, and whole grains.
Metformin is preferred in overweight diabetics and for those gaining weight because taking clozapine for schizophrenia, as it may lead to mild weight loss in comparison to sulfonylureas or insulin. [ 60 ] [ 61 ] The thiazolidinediones , on the other hand, may cause weight gain, but decrease central obesity. [ 62 ]
GLP-1 drugs for weight loss and type 2 diabetes include dulaglutide, liraglutide, and semaglutide. GIP/GLP-1s. These are dual-acting, meaning they target two receptors in the body: gastric ...
Basically, the kind of medication prescribed and dosage affected the weight loss outcome. Semaglutide resulted in more than double the average weight loss of liraglutide (5.1% versus 2.2%).
SGLT2 inhibitors cause the loss of 60–100 grams (2.1–3.5 oz) glucose in the urine each day and are associated with a modest, sustained weight loss of 1.5–2 kilograms (3.3–4.4 lb) in people with type 2 diabetes. The weight loss is less than expected due to compensatory increases in energy intake, but is additive when combined with GLP-1 ...
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