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Clomipramine, sold under the brand name Anafranil among others, is a tricyclic antidepressant (TCA). [7] It is used in the treatment of various conditions, most notably obsessive–compulsive disorder but also many other disorders, including hyperacusis, panic disorder, major depressive disorder, trichotillomania, [8] body dysmorphic disorder [9] [10] [11] and chronic pain. [7]
Patients whose epilepsy is uncontrolled by their medication (i.e., it is refractory to treatment) are selected to see if supplementing the medication with the new drug leads to an improvement in seizure control. Any reduction in the frequency of seizures is compared against a placebo. [21]
Indeed, seizures are greater risk for concern with maprotiline than with all other tricyclic antidepressants [40] (rising from 75 mg, becoming significant at daily doses ≥ 200 m.g.), including clomipramine. It should thus be prescribed with particular, if not extreme, caution to people with a history of epilepsy/seizures of any other kind. In ...
The term seizure threshold is used to describe the balance between excitatory (glutaminergic) and inhibitory (GABA-ergic) forces in the brain which affect how susceptible a person is to seizures. Those diagnosed with epilepsy or certain other neurological conditions are more vulnerable to seizures if the threshold is reduced, and should be ...
A seizure is a paroxysmal episode of symptoms or altered behavior arising from abnormal excessive or synchronous brain neuronal activity. [5] A focal onset seizure arises from a biological neural network within one cerebral hemisphere, while a generalized onset seizure arises from within the cerebral hemispheres rapidly involving both hemispheres.
[8] [13] It may be accompanied by an increase in blood pressure, increase in heart rate, or urinary incontinence. [8] [5] The person may turn blue if breathing is impaired. [8] [5] Shoulder dislocation and tongue biting are also possible. [8] [13] Tonic seizures produce constant contractions of the muscles. The body stiffens for a prolonged ...
ATC code N06 Psychoanaleptics is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products.
Febrile seizures are due to fevers, [12] usually those greater than 38 °C (100.4 °F). [16] The cause of the fevers is often a viral illness. [1] The likelihood of a febrile seizure is related to how high the temperature reaches. [1] [6] Some feel that the rate of increase is not important [1] while others feel the rate of increase is a risk ...
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