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Several groups have identified ways to induce IL-17 production both in vitro [17] and in vivo [18] [19] by distinct cytokines, called TGF-β and IL-6, without the need for IL-23. [ 17 ] [ 18 ] [ 19 ] Although IL-23 is not required for IL-17 expression in this situation, IL-23 may play a role in promoting survival and/or proliferation of the IL ...
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3589 16156 Ensembl ENSG00000095752 ENSMUSG00000004371 UniProt P20809 P47873 RefSeq (mRNA) NM_001267718 NM_000641 NM_008350 NM_001290423 RefSeq (protein) NP_000632 NP_001254647 NP_001277352 NP_032376 Location (UCSC) Chr 19: 55.36 – 55.37 Mb Chr 7: 4.78 – 4.79 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interleukin 11 (IL-11 or adipogenesis inhibitory factor) is a protein that ...
The T h 17 cells can alter their differentiation program ultimately giving rise to either protective or pro-inflammatory pathogenic cells. The protective and non-pathogenic T h 17 cells induced by IL-6 and TGF-β are termed as T reg 17 cells. The pathogenic T h 17 cells are induced by IL-23 and IL-1β. [5]
3605 16171 Ensembl ENSG00000112115 ENSMUSG00000025929 UniProt Q16552 Q62386 RefSeq (mRNA) NM_002190 NM_010552 RefSeq (protein) NP_002181 NP_034682 Location (UCSC) Chr 6: 52.19 – 52.19 Mb Chr 1: 20.8 – 20.8 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interleukin-17A is a protein that in humans is encoded by the IL17A gene. In rodents, IL-17A used to be referred to as CTLA8 ...
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IL-17F together with IL-17A contributes to chronic inflammation. [16] IL-17F may also be involved in tumorigenesis and associated with the tumor microenvironment (TME), as pro-tumor and anti-tumor functions have been ascribed to the related protein IL-17A has. However, a role for IL-17F in tumor development has not been well described. [7]