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  2. PK/PD model - Wikipedia

    en.wikipedia.org/wiki/PK/PD_model

    However, if a delay is observed between the drug administration and the drug effect, a temporal dissociation needs to be taken into account and more complex models exist: [6] [7] Direct vs Indirect link PK/PD models; Direct vs Indirect response PK/PD models [8] Time variant vs time invariant; Cell lifespan models; Complex response models

  3. Metadoxine - Wikipedia

    en.wikipedia.org/wiki/Metadoxine

    In clinical studies, metadoxine has been reported to reduce the half-life of ethanol in healthy volunteers and in acutely intoxicated patients; to accelerate the metabolism of alcohol and acetaldehyde into less toxic higher ketones and to improve their urinary clearance; to restore laboratory variables such as alcohol, ammonia, γ-GT, and alanine aminotransferase; and to improve clinical ...

  4. Quantitative systems pharmacology - Wikipedia

    en.wikipedia.org/wiki/Quantitative_Systems...

    Quantitative systems pharmacology (QSP) is a discipline within biomedical research that uses mathematical computer models to characterize biological systems, disease processes and drug pharmacology. [ 1 ] [ 2 ] QSP can be viewed as a sub-discipline of pharmacometrics that focuses on modeling the mechanisms of drug pharmacokinetics (PK ...

  5. Naltrexone/bupropion - Wikipedia

    en.wikipedia.org/wiki/Naltrexone/bupropion

    Both medications have individually shown some evidence of effectiveness in weight loss, and the combination has been shown to have some synergistic effects on weight. [ 7 ] In September 2014, a sustained release formulation of the drug was approved for marketing in the United States under the brand name Contrave .

  6. Physiologically based pharmacokinetic modelling - Wikipedia

    en.wikipedia.org/wiki/Physiologically_based...

    The drug has an elimination half-life of 4 hours, and an apparent volume of distribution of 10 liters. Pharmacokinetic model of drugs entering a tumor. (A) Schematic illustration of a tumor vessel illustrating loss of smooth muscle cells, local degradation of the extracellular matrix, and increased permeability of the endothelium.

  7. Pharmacodynamics - Wikipedia

    en.wikipedia.org/wiki/Pharmacodynamics

    stabilizing action, the drug seems to act neither as a stimulant or as a depressant (ex.: some drugs possess receptor activity that allows them to stabilize general receptor activation, like buprenorphine in opioid dependent individuals or aripiprazole in schizophrenia, all depending on the dose and the recipient)

  8. Alcohol withdrawal syndrome - Wikipedia

    en.wikipedia.org/wiki/Alcohol_withdrawal_syndrome

    Benzodiazepines are the most commonly used medication for the treatment of alcohol withdrawal and are generally safe and effective in suppressing symptoms of alcohol withdrawal. [33] This class of medication is generally effective in symptoms control, but needs to be used carefully.

  9. Kindling (sedative–hypnotic withdrawal) - Wikipedia

    en.wikipedia.org/wiki/Kindling_(sedative...

    Failure to manage the alcohol withdrawal syndrome appropriately can lead to permanent brain damage or death. [11] Acamprosate, a drug used to promote abstinence from alcohol, an NMDA antagonist drug, reduces excessive glutamate activity in the central nervous system and thereby may reduce excitotoxicity and withdrawal related brain damage. [12 ...