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Paxilline is a toxic, tremorgenic diterpene indole polycyclic alkaloid molecule produced by Penicillium paxilli which was first characterized in 1975. [1] [2] Paxilline is one of a class of tremorigenic mycotoxins, is a potassium channel blocker, and is potentially genotoxic.
Penitrem A (tremortin) is an indole-diterpenoid mycotoxin produced by certain species of Aspergillus, Claviceps, and Penicillium, which can be found growing on various plant species such as ryegrass. [1] Penitrem A is one of many secondary metabolites following the synthesis of paxilline in Penicillium crostosum. [2]
The Lolitrem B toxin derives the first part of its name ('Loli') from the host of the fungus (Lolium perenne), the middle part ('trem') due to the tremors the toxin is known to cause, and the last part of its name ('B') as part of a way to distinguish between different Lolitrems, based on their difference in chemical structure (see 'Chemistry').
"Chemically Different Tremorgenic Mycotoxins in Isolates of Penicillium paxilli from Australia and North America". Journal of Natural Products. 42 (5): 534–6.
There were outbreaks of dog food containing aflatoxin in North America in late 2005 and early 2006, [38] and again in late 2011. [39] Mycotoxins in animal fodder, particularly silage, can decrease the performance of farm animals and potentially kill them. [40] [4] Several mycotoxins reduce milk yield when ingested by dairy cattle. [40]
WASHINGTON (Reuters) -A massive winter storm moving across the United States will not keep the U.S. Congress from meeting on Monday to formally certify Republican Donald Trump's election as ...
“I know [Ukrainian President Volodymyr] Zelenskyy very well, and I know [Russian President Vladimir] Putin very well. I have a good relationship and they respect your president, OK, they respect me.
Fumonisins were the most recent mycotoxin found to affect humans and animals negatively. The most produced toxin for this group of fungi is fumonisin B1. [2] Studies have shown that it can cause diseases such as equine leukoencephalomalacia in horses, hydrothorax and porcine pulmonary edema in swine, and it can negatively affect the immune system.
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