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When anaphylaxis is suspected, epinephrine solution should be given as soon as possible as an intramuscular injection, in the middle of the outer side of the thigh, which corresponds to the location of the vastus lateralis muscle. [3] The injection may be repeated every 5 to 15 minutes if there is insufficient response. [4]
Inhaled epinephrine may be used to improve the symptoms of croup. [12] It may also be used for asthma when other treatments are not effective. [8] It is given intravenously, by injection into a muscle, by inhalation, or by injection just under the skin. [8] Common side effects include shakiness, anxiety, and sweating. [8]
Intramuscular injection, often abbreviated IM, is the injection of a substance into a muscle. In medicine , it is one of several methods for parenteral administration of medications. Intramuscular injection may be preferred because muscles have larger and more numerous blood vessels than subcutaneous tissue, leading to faster absorption than ...
The primary treatment of anaphylaxis is epinephrine injection into a muscle, intravenous fluids, then placing the person "in a reclining position with feet elevated to help restore normal blood flow". [1] [9] Additional doses of epinephrine may be required. [1] Other measures, such as antihistamines and steroids, are complementary. [1]
The US Food and Drug Administration approved the first nasal spray epinephrine drug for severe allergic reactions known as anaphylaxis, providing a needle-free alternative to EpiPens and similar ...
For example, high levels of adrenaline cause smooth muscle relaxation in the airways but causes contraction of the smooth muscle that lines most arterioles. Adrenaline is a nonselective agonist of all adrenergic receptors, including the major subtypes α 1, α 2, β 1, β 2, and β 3. [73]
Neffy's approval is based on four studies in 175 healthy adults without anaphylaxis that measured the epinephrine concentrations in the blood following the administration of Neffy or approved ...
The practice of intracardiac injection originated in the 1800s. It was commonly performed during the 1960s, as it was considered the fastest way to get medication to the heart. The practice began declining during the 1970s as more reliable delivery methods (i.e., intravenous , endotracheal , and intraosseous ) came into use.
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