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Hyperhomocysteinemia is typically managed with vitamin B 6, vitamin B 9 and vitamin B 12 supplementation. [4] Hyperhomocysteinemia is a risk factor for cardiovascular disease; supplements of these vitamins may slightly reduce stroke outcome but not myocardial infarction, death from any cause or adverse events.
Methylenetetrahydrofolate reductase deficiency is the most common genetic cause of elevated serum levels of homocysteine (hyperhomocysteinemia). It is caused by genetic defects in MTHFR, which is an important enzyme in the methyl cycle. [1] Common variants of MTHFR deficiency are asymptomatic and have only minor effects on disease risk. [2]
Hyperhomocysteinemia has been correlated with the occurrence of blood clots, heart attacks, and strokes, although it is unclear whether hyperhomocysteinemia is an independent risk factor for these conditions. [6] Hyperhomocysteinemia has also been associated with early-term spontaneous abortions [7] and with neural tube defects. [8]
Cognitive decline can begin years before signs of dementia set in, which for some can be as early as age 30, a condition known as young-onset dementia.Globally, it’s estimated nearly 4 million ...
Treatment of an age-related neurological disease varies from disease to disease. Modifiable risk factors for dementia include diabetes, hypertension, smoking, hyperhomocysteinemia, hypercholesterolemia, and obesity (which are usually associated with many other risk factors for
By their usual definitions, childhood dementias always cause global neurocognitive decline. In some childhood dementia conditions the child's early development is indistinguishable from their healthy peers, then slows or plateaus before declining. In other childhood dementia disorders, early development may be slower than typical before declining.
Many patients can have leukoaraiosis without any associated clinical abnormality. However, underlying vascular mechanisms are suspected to be the cause of the imaging findings. Hypertension, smoking, diabetes, [3] hyperhomocysteinemia, and heart diseases are all risk factors for leukoaraiosis.
Early onset dementia is less common than late onset dementia, the former accounting for approximately 10% of dementias globally. [3] Recent studies estimate the prevalence of early onset dementia to be approximately 3.55 million people aged 30–64 worldwide, and will triple by 2050. [6] with an incidence of 119 per 100,000 individuals. [1]
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