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This image is a work of the National Institute for Occupational Safety and Health, part of the Centers for Disease Control and Prevention in the United States Department of Health and Human Services, taken or made as part of an employee's official duties.
A closed system drug transfer device or "CSTD" is a drug transfer device that mechanically prohibits the transfer of environmental contaminants into a system and the escape of hazardous drug or vapor concentrations outside the system. Open versus closed systems are commonly applied in medical devices to maintain the sterility of a fluid pathway.
Genotoxicity might involve carcinogenicity, the ability to cause cancer in animal models, humans or both; teratogenicity, which is the ability to cause defects on fetal development or fetal malformation; and lastly hazardous drugs are known to have the potential to cause fertility impairment, which is a major concern for most clinicians. [1]
The Occupational Safety and Health Act gives NIOSH the authority to conduct HHEs in the private sector and federal workplaces. When the workplace is part of a state or local government, NIOSH authority is more limited and the employer's cooperation may be necessary before NIOSH can do an evaluation. [3]
USP 800 (Hazardous Drugs—Handling in Healthcare Settings) is a guideline created by the United States Pharmacopeia Convention (USP), as one of their General Chapters through which the USP "sets quality standards for medicines, dietary supplements and food ingredients".
Hazardous Waste Operations and Emergency Response (HAZWOPER; / ˈ h æ z w ɒ p ər / HAZ-waw-pər) is a set of guidelines produced and maintained by the Occupational Safety and Health Administration which regulates hazardous waste operations and emergency services in the United States and its territories. [1]
Unlike its counterpart, the Occupational Safety and Health Administration, NIOSH's authority under the Occupational Safety and Health Act [29 CFR § 671] is to "develop recommendations for health and safety standards", to "develop information on safe levels of exposure to toxic materials and harmful physical agents and substances", and to "conduct research on new safety and health problems".
Exposure to chemicals in the workplace can cause acute or long-term detrimental health effects. There are many classifications of hazardous chemicals, including neurotoxins, immune agents, dermatologic agents, carcinogens, reproductive toxins, systemic toxins, asthmagens, pneumoconiotic agents, and sensitizers. [4]