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Zonisamide may also interact with other carbonic anhydrase inhibitors to increase the potential for metabolic acidosis. [5] Additionally, the metabolism of zonisamide is inhibited by ketoconazole, ciclosporin, miconazole, fluconazole and carbamazepine (in descending order of inhibition) due to their effects on the CYP3A4 enzyme. [22]
People with epilepsy can have healthy pregnancies and healthy babies. However, proper planning and care is essential to minimize the risk of congenital malformations or adverse neurocognitive outcomes for the fetus while maintaining seizure control for the pregnant person with epilepsy.
Its mechanism of action is thought to be due to antagonism of the postsynaptic T-type voltage-gated calcium channel. [6] Ethosuximide was approved for medical use in the United States in 1960. [7] It is on the World Health Organization's List of Essential Medicines. [8] Ethosuximide is available as a generic medication. [4]
Bupropion/zonisamide (former tentative brand name Empatic, Excalia) is an experimental combination of bupropion which was under development for the treatment of obesity. [1] [2] [3] Bupropion is a norepinephrine–dopamine reuptake inhibitor and nicotinic acetylcholine receptor antagonist, while zonisamide is an anticonvulsant acting as a sodium channel blocker, T-type calcium channel blocker ...
American soldiers were issued a first-aid kit containing sulfa pills and powder and were told to sprinkle it on any open wound. [15] The sulfanilamide compound is more active in the protonated form. The drug has very low solubility and sometimes can crystallize in the kidneys, due to its first pK a of around 10.
Ethoxzolamide, a sulfonamide, inhibits carbonic anhydrase activity in proximal renal tubules to decrease reabsorption of water, sodium, potassium, bicarbonate. It also decreases carbonic anhydrase in the CNS, increasing the seizure threshold.
Early decision (ED) or early acceptance is a type of early admission used in college admissions in the United States for admitting freshmen to undergraduate programs.It is used to indicate to the university or college that the candidate considers that institution to be their top choice through a binding commitment to enroll; in other words, if offered admission under an ED program, and the ...
Early entrance to college, sometimes called early admission or early enrollment, is the practice of allowing students to be accelerated into college, one or more years before the traditional age of college entrance, and without obtaining a high school diploma. In some cases this is done individually.