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Zonisamide may also interact with other carbonic anhydrase inhibitors to increase the potential for metabolic acidosis. [5] Additionally, the metabolism of zonisamide is inhibited by ketoconazole, ciclosporin, miconazole, fluconazole and carbamazepine (in descending order of inhibition) due to their effects on the CYP3A4 enzyme. [22]
People with epilepsy can have healthy pregnancies and healthy babies. However, proper planning and care is essential to minimize the risk of congenital malformations or adverse neurocognitive outcomes for the fetus while maintaining seizure control for the pregnant person with epilepsy.
Its mechanism of action is thought to be due to antagonism of the postsynaptic T-type voltage-gated calcium channel. [6] Ethosuximide was approved for medical use in the United States in 1960. [7] It is on the World Health Organization's List of Essential Medicines. [8] Ethosuximide is available as a generic medication. [4]
Bupropion/zonisamide (former tentative brand name Empatic, Excalia) is an experimental combination of bupropion which was under development for the treatment of obesity. [1] [2] [3] Bupropion is a norepinephrine–dopamine reuptake inhibitor and nicotinic acetylcholine receptor antagonist, while zonisamide is an anticonvulsant acting as a sodium channel blocker, T-type calcium channel blocker ...
American soldiers were issued a first-aid kit containing sulfa pills and powder and were told to sprinkle it on any open wound. [15] The sulfanilamide compound is more active in the protonated form. The drug has very low solubility and sometimes can crystallize in the kidneys, due to its first pK a of around 10.
In the early 1990s, French researchers reported an association of fenfluramine with primary pulmonary hypertension and dyspnea in a small sample of patients. [8] Fenfluramine was withdrawn from the U.S. market in 1997 after reports of heart valve disease [ 48 ] [ 16 ] and continued findings of pulmonary hypertension, including a condition known ...
Early action (EA) is a type of early admission process offered by some institutions for admission to colleges and universities in the United States.Unlike the regular admissions process, EA usually requires students to submit an application by mid-October or early November of their senior year of high school instead of January 1.
An admission note is part of a medical record that documents the patient's status ... a social history is a portion of the admission note addressing familial ...