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Genotoxicity might involve carcinogenicity, the ability to cause cancer in animal models, humans or both; teratogenicity, which is the ability to cause defects on fetal development or fetal malformation; and lastly hazardous drugs are known to have the potential to cause fertility impairment, which is a major concern for most clinicians. [1]
"closed" in relation to chemical contamination and refers to drug transfer devices that mechanically prohibit the transfer of environment contaminants into the system and the escape of hazardous drug or vapor concentrations outside the system. ISOPP, however, agree that the NIOSH definition is the most comprehensive and complete. [11]
USP 800 (Hazardous Drugs—Handling in Healthcare Settings) is a guideline created by the United States Pharmacopeia Convention (USP), as one of their General Chapters through which the USP "sets quality standards for medicines, dietary supplements and food ingredients".
The NIOSH occupational exposure banding process has been created to provide a reliable approximation of a safe exposure level for potentially hazardous and unregulated chemicals in the workplace. [6] Occupational exposure banding uses limited chemical toxicity data to group chemicals into one of five bands. Occupational exposure bands: [7]
NIOSH was created by the Occupational Safety and Health Act of 1970 [27] and began operating in May 1971. [25] It was originally part of the Health Services and Mental Health Administration, and was transferred into what was then called the Center for Disease Control (CDC) in 1973. [27] NIOSH's initial headquarters were located in Rockville ...
The Health Hazard Evaluation (HHE) program is a workplace health program administered by the National Institute for Occupational Safety and Health (NIOSH) by which employees, employers, and labor unions can request assistance from the HHE program at no cost to them.
Exposure to chemicals in the workplace can cause acute or long-term detrimental health effects. There are many classifications of hazardous chemicals, including neurotoxins, immune agents, dermatologic agents, carcinogens, reproductive toxins, systemic toxins, asthmagens, pneumoconiotic agents, and sensitizers. [4]
The exchange rate means that when the noise level is increased by either 3 dBA (according to the NIOSH REL) or 5 dBA (according to the OSHA PEL), the amount of time a person can be exposed to a certain noise level to receive the same dose is cut in half. Exposures at or above these levels are considered hazardous.