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Dermatophagoides pteronyssinus Dust mite faecal pellets that can be small as 10 μm, [1] but can be contained by anti-mite fabrics of a denser pore size. [2]House dust mites (HDM, or simply dust mites) are various species of acariform mites belonging to the family Pyroglyphidae that are found in association with dust in dwellings. [3]
The clearance of rapidly opsonised microfilariae from the bloodstream results in a hypersensitive immunological process and abnormal recruitment of eosinophils, as reflected by extremely high IgE levels of over 1000 kU/L. [5] [9] The typical patient is a young adult man from the Indian subcontinent.
HDM-SLIT tablet, House Dust Mites (Dermatophagoides farinae and Dermatophagoides pteronyssinus) Allergen Extract (brand names: Odactra, Acarizax, Miticure), is an allergen extract for the immunotherapic treatment of adolescents (12–17 years) [35] and adults (18–65 years).
IgE antibodies against plant/insect CCD determinants were shown to have both strict specificity and high affinity, so in principle they might be expected to lead to clinical symptoms just as habitual for anti-peptide IgE. In vitro experiments (histamine-release tests) with polyvalent glyco-allergens corroborated this view.
Compared to other forms of peptidase 1, Pso o 1 shares 54% identity with Der f 1, 53% identity with Der p 1, and 53% identity with Eur m 1. [10] A number of amino acid sequences from other peptidase 1 enzymes are shown to be conserved in Pso o 1, including enzymatic amino acids, a N-glycosylation site, and the Der p 1 epitope Leu 147-Gln 160. [10]
Immunoglobulin E (IgE) is a type of antibody (or immunoglobulin (Ig) "isoform") that has been found only in mammals. IgE is synthesised by plasma cells. Monomers of IgE consist of two heavy chains (ε chain) and two light chains, with the ε chain containing four Ig-like constant domains (Cε1–Cε4). [1]
The RAST is a radioimmunoassay test to detect specific IgE antibodies to suspected or known allergens for the purpose of guiding a diagnosis about allergy. [10] [11] IgE is the antibody associated with Type I allergic response: for example, if a person exhibits a high level of IgE directed against pollen, the test may indicate the person is allergic to pollen (or pollen-like) proteins.
Three species of house dust mite are commonly found in human dwellings; Dermatophagoides farinae, Dermatophagoides pteronyssinus and Euroglyphus maynei.They feed on flakes of skin found in dust and typically occur on carpets, around sofas and chairs, and on mattresses.