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A protein is predicted to be "druggable" if it is a member of a protein family [4] for which other members of the family are known to be targeted by drugs (i.e., "guilt" by association). While this is a useful approximation of druggability, this definition has limitations for two main reasons: (1) it highlights only historically successful ...
Specificity for a set of ligands is unrelated to the ability of an enzyme to catalyze a given reaction, with the ligand as a substrate. [ 1 ] If a given enzyme has a high chemical specificity, this means that the set of ligands to which it binds is limited, such that neither binding events nor catalysis can occur at an appreciable rate with ...
[1] [2] Some of the commonly used grades of purity include: ACS grade is the highest level of purity, and meets the standards set by the American Chemical Society (ACS). The official descriptions of the ACS levels of purity is documented in the Reagent Chemicals publication, issued by the ACS. [3] [4] It is suitable for food and laboratory uses.
The Schiff test detects aldehydes; Tollens' reagent tests for aldehydes (known as the silver mirror test) The Zeisel determination tests for the presence of esters or ethers; Lucas' reagent is used to distinguish between primary, secondary and tertiary alcohols. The bromine test is used to test for the presence of unsaturation and phenols.
In chemistry a donor number (DN) is a quantitative measure of Lewis basicity.A donor number is defined as the negative enthalpy value for the 1:1 adduct formation between a Lewis base and the standard Lewis acid SbCl 5 (antimony pentachloride), in dilute solution in the noncoordinating solvent 1,2-dichloroethane with a zero DN.
In medical diagnosis, test sensitivity is the ability of a test to correctly identify those with the disease (true positive rate), whereas test specificity is the ability of the test to correctly identify those without the disease (true negative rate). If 100 patients known to have a disease were tested, and 43 test positive, then the test has ...
They are a set of modified Western Electric rules, developed by James Westgard and provided in his books and seminars on quality control. [1] They are plotted on Levey–Jennings charts, wherein the X-axis shows each individual sample, and the Y-axis shows how much each one differs from the mean in terms of standard deviation (SD). The rules ...
The reagent is typically provided in two parts: [2] [1] [3] A mixture of 2% sodium nitroprusside and 2% acetaldehyde in water (solution A) [4] A solution of 2% sodium carbonate in water (solution B) [4] Separate storage of the aldehyde and base are necessary to prevent aldol polymerisation of the aldehyde.