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An miRNA that remains constant in its expression through these stages is proposed to have a role in regulating general aspects of cell physiology. [8] Thus it was becoming evident in 2003 shortly after its discovery, that the mir-92 miRNA and associated family members are providing functional roles to the cell cycle and to cell signalling, and ...
miRNA biogenesis in plants differs from animal biogenesis mainly in the steps of nuclear processing and export. Instead of being cleaved by two different enzymes, once inside and once outside the nucleus, both cleavages of the plant miRNA are performed by a Dicer homolog, called Dicer-like1 (DL1). DL1 is expressed only in the nucleus of plant ...
The miR-15 microRNA precursor family is made up of small non-coding RNA genes that regulate gene expression. The family includes the related mir-15a and mir-15b sequences, as well as miR-16-1, miR-16-2, miR-195 and miR-497.
Each member of miR-125 family has two different variants of mature miRNAs - 5p and 3p. Both variants originate from the same pre-miRNA. MiR-125-5p variant generally shows higher expression compared to miR-125-3p. [6] In humans, miR-125 family is composed of three homologs: hsa-miR-125a, hsa-miR-125b-1 and hsa-miR-125b-2. [7]
406947 n/a Ensembl ENSG00000283904 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 21: 25.57 – 25.57 Mb n/a PubMed search n/a Wikidata View/Edit Human MiR-155 is a microRNA that in humans is encoded by the MIR155 host gene or MIR155HG. MiR-155 plays a role in various physiological and pathological processes. [7] [8] [9] Exogenous molecular control in ...
The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer. [1] This sequence then associates with RISC which effects RNA interference. [2] miR-150 functions in hematopoiesis; it regulates genes whose downstream products encourage differentiating stem cells towards becoming megakaryocytes rather than ...
StarBase; Content; Description: microRNA-mRNA interaction maps from Argonaute CLIP-Seq and Degradome-Seq data.: Contact; Research center: Sun Yat-sen University: Laboratory: Key Laboratory of Gene Engineering of the Ministry of Education
A miRNA can be derived from each arm of the pre-miRNA hairpin. Historically, the least common of these two miRNA products was denoted by the addition of * to the miRNA name, however the modern convention is to denote mature miRNA products as 5p or 3p. [11] Both mir-10 and mir-10* have been detected in Drosophila.