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2. Antimigraine drug - Wikipedia

   en.wikipedia.org/wiki/Antimigraine_drug

   CGRP antagonists can be used for both acute migraine treatment as well as prophylactically. [14] CGRP is a neuropeptide which is thought to induce migraines via vasodilation of cranial arteries. [14] CGRP can also release inflammatory agents and cause nervous system sensitization. [14]

3. List of antidepressants - Wikipedia

   en.wikipedia.org/wiki/List_of_antidepressants

   Etryptamine [α-Ethyltryptamine (αET)] (Monase) – non-selective serotonin receptor agonist, SNDRA, and weak RIMA; Indeloxazine (Elen, Noin) – serotonin releasing agent (SRA), NRI, and NMDA receptor antagonist; Oxaflozane (Conflictan) – 5-HT 1A, 5-HT 2A, and 5-HT 2C receptor agonist; Pivagabine (Tonerg) – unknown/unclear mechanism of action

4. Management of migraine - Wikipedia

   en.wikipedia.org/wiki/Management_of_migraine

   Rescue treatment involves acute symptomatic control with medication. [4] Recommendations for rescue therapy of migraine include: (1) migraine-specific agents such as triptans, CGRP antagonists, or ditans for patients with severe headaches or for headaches that respond poorly to analgesics, (2) non-oral (typically nasal or injection) route of administration for patients with vomiting, (3) avoid ...

5. Dihydroergotamine - Wikipedia

   en.wikipedia.org/wiki/Dihydroergotamine

   DHE's antimigraine activity is due to its action as an agonist at the serotonin 5-HT 1B, 5-HT 1D, and 5-HT 1F receptors. It also interacts with other serotonin, adrenergic, and dopamine receptors. [14] DHE is an agonist of the serotonin 5-HT 2B receptor and has been associated with cardiac valvulopathy. [15]

6. Serotonin–norepinephrine–dopamine reuptake inhibitor

   en.wikipedia.org/wiki/Serotonin–norepinephrine...

   In accordance with this, drugs that affect 5-HT-containing cells or 5-HT receptors are effective treatments for numerous indications, including depression, anxiety, obesity, nausea, and migraine. Because serotonin and the related hormone melatonin are involved in promoting sleep, they counterbalance the wake-promoting action of increased ...

7. Noradrenergic and specific serotonergic antidepressant

   en.wikipedia.org/wiki/Noradrenergic_and_specific...

   They act by antagonizing the α 2-adrenergic receptor and certain serotonin receptors such as 5-HT 2A and 5-HT 2C, [1] but also 5-HT 3, [1] 5-HT 6, and/or 5-HT 7 in some cases. By blocking α 2 -adrenergic autoreceptors and heteroreceptors , NaSSAs enhance adrenergic and serotonergic neurotransmission in the brain involved in mood regulation ...