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Sirtuin 1, also known as NAD-dependent deacetylase sirtuin-1, is a protein that in humans is encoded by the SIRT1 gene. [5] [6] [7]SIRT1 stands for sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae), referring to the fact that its sirtuin homolog (biological equivalent across species) in yeast (Saccharomyces cerevisiae) is Sir2.
SIRT1 protein promotes homologous recombination in human cells and is involved in recombinational repair of DNA breaks. [ 29 ] SIRT6 is a chromatin -associated protein and in mammalian cells is required for base excision repair of DNA damage . [ 30 ]
In September 2003, Howitz and Sinclair et al. published a highly cited paper reporting that polyphenols such as resveratrol [2] activate human SIRT1 and extend the lifespan of budding yeast (Howitz et al., Nature, 2003).
4837 18113 Ensembl ENSG00000166741 ENSMUSG00000032271 UniProt P40261 O55239 RefSeq (mRNA) NM_006169 NM_001311062 NM_010924 RefSeq (protein) NP_006160 NP_001358974 NP_001358975 NP_001358976 NP_001297991 NP_035054 Location (UCSC) Chr 11: 114.26 – 114.31 Mb Chr 9: 48.5 – 48.52 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Nicotinamide N-methyltransferase (NNMT) is an enzyme that ...
SRT-1720 is an experimental drug that was studied by Sirtris Pharmaceuticals intended as a small-molecule activator of the sirtuin subtype SIRT1. The compound has been studied in animals, but safety and efficacy in humans have not been established.
She also suggests celebrating the other healthy things you do to live longer and combat cancer, like eating veggies, lifting weights, and drinking water. “We never say, ‘Hey, nice job, we had ...
From the luxury real estate ads in the Aspen airport to views of mansions from the town's gondola, it was clear from the moment I arrived in the ski town that owning property in Aspen takes a lot ...
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