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Petrunkin and Petrunkin (1927, 1928) appear to be the first who studied the binding of GnHCl to gelatin and a mixture of thermally denatured protein from brain extract. . Greenstein (1938, 1939), however, appears to be the first to discover the high denaturing action of guanidinium halides and thiocyanates in following the liberation of sulfhydryl groups in ovalbumin and other proteins as a ...
The general structure of a guanidine. Guanidines are a group of organic compounds sharing a common functional group with the general structure (R 1 R 2 N)(R 3 R 4 N)C=N−R 5. The central bond within this group is that of an imine, and the group is related structurally to amidines and ureas.
Tetramethylguanidine is an organic compound with the formula HNC(N(CH 3) 2) 2. This colourless liquid is a strong base, as judged by the high pK a of its' conjugate acid. [2] It was originally prepared from tetramethylthiourea via S-methylation and amination, but alternative methods start from cyanogen iodide. [3]
Guanidinium thiocyanate can be used to deactivate a virus, such as the influenza virus that caused the 1918 "Spanish flu", so that it can be studied safely.. Guanidinium thiocyanate is also used to lyse cells and virus particles in RNA and DNA extractions, where its function, in addition to its lysing action, is to prevent activity of RNase enzymes and DNase enzymes by denaturing them.
Arginine is the amino acid with the formula (H 2 N)(HN)CN(H)(CH 2) 3 CH(NH 2)CO 2 H. The molecule features a guanidino group appended to a standard amino acid framework. At physiological pH, the carboxylic acid is deprotonated (−CO 2 − ) and both the amino and guanidino groups are protonated, resulting in a cation.
Molar mass: 151.13 g/mol ... With the formula C 5 H 5 N 5 O, ... Emil Fischer determined the structure and also showed that uric acid can be converted to guanine. [4]
EC Number: 203-309-0; ... Chemical formula. C 5 H 7 N O 2: Molar mass: ... ethyl cyanoacetate and guanidine can be used as starting material in a multi-stage ...
Pimagedine, also known as aminoguanidine, is an investigational drug for the treatment of diabetic nephropathy that is no longer under development as a drug. [1] Pimagedine functions as an inhibitor of diamine oxidase and nitric oxide synthase.