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Clostridial necrotizing enteritis (CNE) is a severe and potentially fatal type of food poisoning caused by a β-toxin of Clostridium perfringens, [1] Type C. It occurs in some developing regions, particularly in New Guinea, where it is known as pig-bel.
Clostridium perfringens is a common cause of food poisoning in the United States. C. perfringens produces spores, and when these spores are consumed, they produce a toxin that causes diarrhea. Foods cooked in large batches and held at unsafe temperatures (between 40 °F and 140 °F) are the source of C. perfringens food
Though an effective antibiotic when all others fail, against extremely drug resistant infections, it has many side effects. including inhibition of monoamine oxidase, [1] and as with other nitrofurans generally, minimum inhibitory concentrations also produce systemic toxicity, resulting in tremors, convulsions, peripheral neuritis ...
Clostridium species (Clostridium perfringens, Clostridium septicum, and Clostridium sordellii) [4] In polymicrobial (mixed) infections, Group A Streptococcus (S. pyogenes) is the most commonly found bacterium, followed by S. aureus. [10] However, when the infection is caused solely by S. pyogenes and/or S. aureus, it is classified as a Type II ...
usually Clostridium perfringens; other Clostridium species Gas gangrene (Clostridial myonecrosis) No Geotrichum candidum: Geotrichosis: No PRNP: Gerstmann-Sträussler-Scheinker syndrome (GSS) No Giardia lamblia: Giardiasis: Detection of antigens on the surface of organisms in stool Treatment is not always necessary.
The major virulence factor of C. perfringens is the CPE enterotoxin, which is secreted upon invasion of the host gut, and contributes to food poisoning and other gastrointestinal illnesses. [3] It has a molecular weight of 35.3 kDa, and is responsible for the disintegration of tight junctions between epithelial cells in the gut. [6]
Repeated aspirations of an abscess are preferable in those with multiple abscesses or when the abscess is located in a predominate brain site. Administration of antimicrobials in a high-dose for an extended period of time can offer an alternative treatment strategy in this type of patients and may substitute for surgical evacuation of an abscess.
Minocycline was a commonly used tetracycline synthesized in Lederle Laboratories in 1970, but antibiotic resistance to the drug began growing in prevalence throughout the 70's and 80's. [30] [31] While the problem of antibiotic resistance was known to scientists during the 1980s, apathy led to little federal attention given to the emerging ...