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Gallium (68 Ga) gozetotide or Gallium (68 Ga) PSMA-11 sold under the brand name Illuccix among others, is a radiopharmaceutical made of 68 Ga conjugated to prostate-specific membrane antigen (PSMA) targeting ligand, Glu-Urea-Lys(Ahx)-HBED-CC, used for imaging prostate cancer by positron emission tomography (PET). [11]
Gallium-67 citrate is produced by a cyclotron. Charged particle bombardment of enriched Zn-68 is used to produce gallium-67. The gallium-67 is then complexed with citric acid to form gallium citrate. The half-life of gallium-67 is 78 hours. [45] It decays by electron capture, then emits de-excitation gamma rays that are detected by a gamma camera.
53320 Ensembl ENSG00000086205 ENSMUSG00000001773 UniProt Q04609 O35409 RefSeq (mRNA) NM_001014986 NM_001193471 NM_001193472 NM_001193473 NM_004476 NM_001351236 NM_001159706 NM_016770 RefSeq (protein) NP_001014986 NP_001180400 NP_001180401 NP_001180402 NP_004467 NP_001338165 NP_001153178 NP_058050 Location (UCSC) Chr 11: 49.15 – 49.21 Mb Chr 7: 86.37 – 86.43 Mb PubMed search Wikidata View ...
After injection, imaging of positron emitters such as gallium-68 (68 Ga), copper-64 (64 Cu), and fluorine-18 (18 F) is carried out with a positron emission tomography (PET) scanner. For gamma emitters such as technetium-99m ( 99m Tc) and indium-111 ( 111 In) single-photon emission computed tomography (SPECT) imaging is performed with a gamma ...
It is the longest-lived radioisotope of gallium. The shorter-lived gallium-68 (half-life 68 minutes) is a positron-emitting isotope generated in very small quantities from germanium-68 in gallium-68 generators or in much greater quantities by proton bombardment of 68 Zn in low-energy medical cyclotrons, [4] [5] for use in a small minority of ...
An endoscopy can examine the esophagus, stomach and part of the small intestines, and CT scans may be used to check for tumors or structural abnormalities in the head, neck or chest.
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The parent isotope germanium-68 is the longest-lived (271 days) of the radioisotopes of germanium. It has been produced by several methods. [1] In the U.S., it is primarily produced in proton accelerators: At Los Alamos National Laboratory, it may be separated out as a product of proton capture, after proton irradiation of Nb-encapsulated gallium metal. [2]