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The binding of a ligand to the receptor causes a conformation change in the receptor. This conformation change can affect the activity of the receptor and result in the production of active second messengers. [citation needed] In the case of G protein-coupled receptors, the conformation change exposes a binding site for a G-protein.
Two molecular mechanisms for synaptic plasticity involve the NMDA and AMPA glutamate receptors. Opening of NMDA channels (which relates to the level of cellular depolarization) leads to a rise in post-synaptic Ca 2+ concentration and this has been linked to long-term potentiation, LTP (as well as to protein kinase activation); strong depolarization of the post-synaptic cell completely ...
By this time it was known that long-term memory, unlike short-term memory, involved the synthesis of new proteins. By 1972 they had evidence that the second messenger molecule cyclic AMP (cAMP) was produced in Aplysia ganglia under conditions that cause short-term memory formation (sensitization). In 1974 Kandel moved his lab to Columbia ...
A number of studies utilizing a variety of methods such as histological, structural imaging, functional imaging, and receptor binding have supplied converging evidence that the frontal lobes and frontal-striatal dopaminergic pathways are especially affected by age-related processes resulting in memory changes. [6]
This provided early evidence that the NMDA receptor — and by extension, LTP — was required for at least some types of learning and memory. Similarly, Susumu Tonegawa demonstrated in 1996 that the CA1 area of the hippocampus is crucial to the formation of spatial memories in living mice. [ 58 ]
Kainate receptors are expressed in a variety of brain regions and are involved in processes such as sensory processing, motor control, and learning and memory. Each subtype of glutamate receptor has a unique function and plays a crucial role in neuronal communication and plasticity.
The third reason is the "memory self-efficacy," which indicates that older people do not have confidence in their own memory performances, leading to poor consequences. [17] It is known that patients with Alzheimer's disease and patients with semantic dementia both exhibit difficulty in tasks that involve picture naming and category fluency.
Age-related differences in cognitive functioning have been known to stem from the reduction of cognitive resources available, thus impairing older adults’ ability to carry out cognitively demanding tasks. [3] Cognitive aging causes changes in mechanisms related to information processing and working memory function.