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The paramesonephric ducts play a critical role in the female reproductive tract and differentiate to form the uterine tubes, uterus, superior vagina as well as the uterine cervix. Many types of disorders can occur when this system is disrupted ranging from uterine and vaginal agenesis to the duplication of unwanted cells of the uterus and vagina.
In the female, the paramesonephric ducts persist and undergo further development. The portions which lie in the genital cord [citation needed] fuse to form the uterus and vagina. This fusion of the paramesonephric ducts begins in the third month, and the septum formed by their fused medial walls disappears from below upward.
The internal genitalia consist of two accessory ducts: mesonephric ducts (male) and paramesonephric ducts (female). The mesonephric system is the precursor to the male genitalia and the paramesonephric to the female reproductive system. [8] As development proceeds, one of the pairs of ducts develops while the other regresses.
By 8 weeks post-conception, the human mesonephros reaches maximum size and begins to regress, with complete regression occurring by week 16. [6] Despite its transiency, the mesonephros is crucial for the development of structures such as the Wolffian duct (or mesonephric duct), which in turn gives rise to the ureteric bud of the metanephric kidney.
m, m. Right and left Müllerian ducts uniting together and running with the Wolffian ducts in gc, the genital cord: m. Müllerian duct, the upper part of which remains as the hydatid of Morgagni; the lower part, represented by a dotted line descending to the prostatic utricle, constitutes the occasionally existing cornu and tube of the uterus ...
The human female reproductive system consists of the gonads, external genitalia and the Müllerian duct system. [28] Initially in the embryo, both the Wolffian (mesonephric) and Müllerian (paramesonephric) ducts are present, where development of the Wolffian ducts give rise to the male reproductive tract and development of the Müllerian ducts ...
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As a component of the female reproductive system, the cervix is derived from the two paramesonephric ducts (also called Müllerian ducts), which develop around the sixth week of embryogenesis. During development, the outer parts of the two ducts fuse, forming a single urogenital canal that will become the vagina, cervix and uterus. [14]