Search results
Results from the WOW.Com Content Network
Alzheimer's first substantive description of plaques appeared in 1911. [11] In contrast, Oskar Fischer published a series of comprehensive investigations of plaques and dementia in 1907, 1910 and 1912. [11] By 1911, Max Bielschowsky proposed the amyloid-nature of plaque deposits.
Amyloid, a misfolded and insoluble protein, can become a deposit in the heart's atria, valves, or ventricles. These deposits can cause thickening of different sections of the heart, leading to decreased cardiac function. [1] The overall decrease in cardiac function leads to a plethora of symptoms. [2]
The reasons why amyloid cause diseases are unclear. In some cases, the deposits physically disrupt tissue architecture, suggesting disruption of function by some bulk process. An emerging consensus implicates prefibrillar intermediates, rather than mature amyloid fibers, in causing cell death, particularly in neurodegenerative diseases.
Plaque build-up often doesn’t cause symptoms, but it can block blood flow to vital organs like your heart. Coronary artery disease occurs when atherosclerosis affects the arteries supplying ...
If the heart attack is not fatal, fibrous organization of the clot within the lumen ensues, covering the rupture but also producing stenosis or closure of the lumen, or over time and after repeated ruptures, resulting in a persistent, usually localized stenosis or blockage of the artery lumen. Stenoses can be slowly progressive, whereas plaque ...
70–80% of those with AL amyloidosis have heart involvement, and heart involvement is the leading cause of death. [4] Heart complications, include heart failure and irregular heart beat. Early heart involvement in AL amyloidosis may present as low voltage electrical rhythms on an electrocardiograph, concentric left ventricular hypertrophy and ...
“To consider that an increase in amyloid-beta plaques levels as an unintended effect of the new anti-monoclonal antibody class of drugs may actually be part of the helpful mechanism of action ...
File:Heart attack cause diagram.svg. Add languages. ... Information from its description page there is shown below. Commons is a freely licensed media file repository.