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The TRIUMF facility and Canadian Nuclear Laboratories have formed a strategic partnership around the commercial production of actinium-225. [11] The low supply of 225 Ac limits its use in research and cancer treatment. It is estimated that the current supply of 225 Ac only allows about a thousand cancer treatments per year. [7] [12]
Listed here are mainly average market prices for bulk trade of commodities. Data on elements' abundance in Earth's crust is added for comparison. As of 2020, the most expensive non-synthetic element by both mass and volume is rhodium. It is followed by caesium, iridium and palladium by mass and iridium, gold and platinum by volume.
The ligand is the target binding site, it may be on the surface of the targeted cancer cell for therapeutic purposes. Radioisotopes can occur naturally or be synthesized and produced in a cyclotron/nuclear reactor. The different types of radioisotopes include Y-90, H-3, C-11, Lu-177, Ac-225, Ra-223, In-111, I-131, I-125, etc.
Fusion Pharmaceuticals uses a chemical element which helps target and kill cancer cells while minimising damage to surrounding healthy cells. AstraZeneca buys Canadian cancer treatment firm for ...
This is made by the alpha decay of actinium-225. The generation of one short-lived isotope from longer lived isotope is a useful method of providing a portable supply of a short-lived isotope. This is similar to the generation of technetium-99m by a technetium generator. The actinium-225 is made by the irradiation of radium-226 with a cyclotron ...
Actinium-227 (half-life 21.8 years) in turn decays via thorium-227 (half-life 18.7 days) to radium-223. This decay path makes it convenient to prepare radium-223 by "milking" it from an actinium-227 containing generator or "cow", similar to the moly cows widely used to prepare the medically important isotope technetium-99m .
Additionally, 225 Ac decays to nontoxic 209 Bi rather than toxic lead, which is the final product in the decay chains of several other candidate isotopes, namely 227 Th, 228 Th, and 230 U. [28] Not only 225 Ac itself, but also its daughters, emit alpha particles which kill cancer cells in the body.
228 Ac and 225 Ac are extremely rare, so almost all natural actinium is 227 Ac. The most stable isotopes are 227 Ac with a half-life of 21.772 years, 225 Ac with a half-life of 10.0 days, and 226 Ac with a half-life of 29.37 hours. All other isotopes have half-lives under 10 hours, and most under a minute.